The field of colorectal surgery has evolved over the millennia, shaped by the continuous interplay of cultural values, anatomical discoveries, and technological advances. From the ancient Egyptian papyri that detailed anorectal conditions and therapeutic enemas to the empirical innovations of Greek and Roman physicians, the early approach to surgery was curious yet pragmatic. Although classical medicine introdu...
Colorectal cancer (CRC) is a highly diverse disease, where different genomic instability pathways shape genetic clonal diversity and tumor microenvironment. Although intra-tumor heterogeneity has been characterized in primary tumors, its origin and consequences in CRC outcome is not fully understood. Therefore, we assessed intra- and inter-tumor heterogeneity of a prospective cohort of 136 CRC samples. We demon...
An anatomic rare variation disclosed during a D2 dissection and total gastrectomy for gastric cancer.; An anatomic rare variation disclosed during a D2 dissection and total gastrectomy for gastric cancer.
In Portugal, insurance policies for fleets of vehicles are, in general, similar to policies for individual vehicles. Such is the case of the insurance company at hand. The experience rating system is practically the same as in individual motor insurance and is applied independently to each vehicle, thus having no effect on the premium paid by other vehicles in the fleet. This experience rating system is ineffic...
Dada a verificação da existência de inúmeros incidentes de várias origens, em toda a vida útil de um qualquer edifício, foi publicado em 12 de novembro de 2008 o Decreto-Lei n.º 220/2008, o qual estabeleceu o novo Regime Jurídico da Segurança Contra Incêndios em Edifícios (SCIE). Este novo diploma procurou garantir que os novos edifícios, bem como os já existentes, dispusessem de um maior grau de segurança para...
Introduction: Oesophagectomy for cancer is associated to a significant morbidity and mortality. The superiority of transthoracic vs transhiatal is still a matter of controversy. The aim of this paper is to discuss the results of a series of patients submitted to either a transthoracic or a transhiatal according to the anatomic location regarding the carina.Material and Methods: Retrospective analysis of 52 cons...
Introduction: Anastomotic complications are responsible for significant morbidity after oesophagectomy for cancer. Cervical oesophagogastrostomy is associated with high incidence of anastomotic leaks (0 – 18%) and stenosis (1- 43%). The aim of this study was to address the reliability of our method of preparation of the gastric tube, the pull-up of the gastric conduit and the esophagogastrostomy, based on a con...
Este artigo apresenta o resultado de uma investigação académica sobre a Gestão de Serviços de Tecnologias de Informação (GSTI) realizada num organismo público na Região Autónoma da Madeira (RAM), a Secretaria Regional da Cultura, Turismo e Transportes (SRT) em 2012. Optou-se pelo processo Gestão da Configuração do Information Technology Infrastructure Library (ITIL), como um modelo a implementar nesta organizaç...
This paper presents the preliminary results of an academic research about implementation of an Information Technology Infrastructure Library (ITIL) process conducted in 2012 in a Portuguese public organization named Culture, Tourism and Transport Regional Department of Madeira Autonomous Region. During the process we encountered resistance against ITIL and adversity to change. It is also true that other factors...
Introduction: We report the case of a patient with classical congenital adrenal hyperplasia due to 21-hydroxylase deficiency who presented with unusual anatomical and biochemical features, namely massively enlarged adrenal glands, adrenogenital rest tissue and an unexpected endocrine profile. The contribution of the adrenocortical cells in the adrenals and testicles was determined by a cosyntropin stimulation t...