14 documents found, page 1 of 2

Metabolic profiling of maternal urine can aid clinical management of gestationa...

Introduction The clinical management of Gestational diabetes mellitus (GDM) would benefit from enhanced metabolic knowledge both at the time of diagnosis and during therapy. Objectives This work aimed at unveiling metabolic markers of GDM and of the subjects' response to therapy. Methods Urine NMR metabolomics was used with a variable selection methodology to reduce uninformative variability. The NMR data was a...

Newborn Urinary Metabolic Signatures of Prematurity and Other Disorders: A Case...

This work assesses the urinary metabolite signature of prematurity in newborns by nuclear magnetic resonance (NMR) spectroscopy, while establishing the role of possible confounders and signature specificity, through comparison to other disorders. Gender and delivery mode are shown to impact importantly on newborn urine composition, their analysis pointing out at specific metabolite variations requiring consider...

Impact of fetal chromosomal disorders on maternal blood metabolome: toward new ...

This study aimed at determining the relationship between fetal chromosomal disorders (CDs), including trisomy 21 (T21), and on first and second trimester maternal blood plasma, to identify the time course metabolic adaptations to the conditions and the possible new plasma biomarkers. Furthermore, a definition of a joint circulatory (plasma) and excretory (urine) metabolic description of second trimester CDs was...

Following Healthy Pregnancy by NMR Metabolomics of Plasma and Correlation to Urine

This work presents the first NMR metabolomics study of maternal plasma during pregnancy, including correlation between plasma and urine metabolites. The expected decrease in circulating amino acids early in pregnancy was confirmed with six amino acids being identified as required by the fetus in larger extents. Newly observed changes in citrate, lactate, and dimethyl sulfone suggested early adjustments in energ...

Prediction of Gestational Diabetes through NMR Metabolomics of Maternal Blood

Metabolic biomarkers of pre- and postdiagnosis gestational diabetes mellitus (GDM) were sought, using nuclear magnetic resonance (NMR) metabolomics of maternal plasma and corresponding lipid extracts. Metabolite differences between controls and disease were identified through multivariate analysis of variable selected 1H NMR spectra. For postdiagnosis GDM, partial least squares regression identified metabolites...

Impact of fetal chromosomal disorders on maternal blood metabolome: toward new ...

OBJECTIVE: This study aimed at determining the relationship between fetal chromosomal disorders (CDs), including trisomy 21 (T21), and on first-and second-trimester maternal blood plasma, to identify the time-course metabolic adaptations to the conditions and the possible new plasma biomarkers. Furthermore, a definition of a joint circulatory (plasma) and excretory (urine) metabolic description of second-trimes...

Following Healthy Pregnancy by NMR Metabolomics of Plasma and Correlation to Urine

This work presents the first NMR metabolomics study of maternal plasma during pregnancy, including correlation between plasma and urine metabolites. The expected decrease in circulating amino acids early in pregnancy was confirmed with six amino acids being identified as required by the fetus in larger extents. Newly observed changes in citrate, lactate, and dimethyl sulfone suggested early adjustments in energ...

Prediction of Gestational Diabetes through NMR Metabolomics of Maternal Blood

Metabolic biomarkers of pre- and postdiagnosis gestational diabetes mellitus (GDM) were sought, using nuclear magnetic resonance (NMR) metabolomics of maternal plasma and corresponding lipid extracts. Metabolite differences between controls and disease were identified through multivariate analysis of variable selected H-1 NMR spectra. For postdiagnosis GDM, partial least squares regression identified metabolite...

Maternal plasma phospholipids are altered in trisomy 21 cases and prior to pree...

Human plasma stability during handling and storage: impact on NMR metabolomics

This work contributes to fill in some existing gaps in the knowledge of human plasma degradability during handling and storage, a paramount issue in Nuclear Magnetic Resonance (NMR) metabolomics. Regarding the comparison between heparin and EDTA anti-coagulant collection tubes, the former showed no interference of the polysaccharide, while conserving full spectral information. In relation to time/temperature co...