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In vitro bioaccessibility and intestinal transport of retinoic acid in ethyl ce...

Gonçalves, A; Viegas, Olga; Faria, A; Ferreira, MPLVO; Rocha, F; Estevinho, N

The development of carrier-based delivery systems for oral administration of retinoic acid (RA), that provides its release and absorption at intestinal level, is of major relevance in the treatment of acute promyelocytic leukemia. The aim of this work was to evaluate RA bioaccessibility and intestinal transport on ethyl cellulose (EC)- and EC + polyethylene glycol (ECP)-based microparticles and to understand th...


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