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Mixed methemoglobinemia, congenital and acquired
Murinello, António; Bicho, Manuel; Estrela Inácio, Rosa; Loureiro, Maria ConceiçãoThe authors present a case of acute methaemoglobinaemia of mixed aetiology - congenital and acquired. Excessive cutaneous absorption of aniline dye was the causal factor, but an associated moderate defect in cytochrome-b reductase as well as a glucose-6-phosphate dehydrogenase (G6PD) deficiency aggravated the clinicai course of the disease. Therapy with methylene blue was effective, but it cau...
Methemoglobinemia
Murinello, António; Bicho, Manuel; Estrela Inácio, Rosa; Loureiro, Maria ConceiçãoMethemoglobinemia refers to the existence of high blood concentrations of methemoglobin, resulting from the oxidation offerrous iron to ferric iron within the hemoglobin molecule. An extensive review of methemoglobinemia is done, initiaJJy focusing on physiological enzymatic mechanisms of oxidation/ reduction of hemoglobin, referring its efficacy in pathologic methemoglobinemia. Methe moglobinemia causes tissu...