20 documents found, page 1 of 2
Licochalcone A: A Potential Multitarget Drug for Alzheimer's Disease Treatment
Olloquequi, Jordi; Ettcheto, Miren; Cano, Amanda; Fortuna, A.; Bicker, Joana; Sánchez-López, Elena; Paz, Cristian; Ureña, Jesús; Verdaguer, EsterLicochalcone A (Lico-A) is a flavonoid compound derived from the root of the Glycyrrhiza species, a plant commonly used in traditional Chinese medicine. While the Glycyrrhiza species has shown promise in treating various diseases such as cancer, obesity, and skin diseases due to its active compounds, the investigation of Licochalcone A's effects on the central nervous system and its potential application in Alz...
Biodegradable nanoparticles for the treatment of epilepsy: From current advance...
Bonilla, Lorena; Esteruelas, Gerard; Ettcheto, Miren; Espina, Marta; García, María Luisa; Camins, Antoni; Souto, Eliana B.; Cano, AmandaEpilepsy is the second most prevalent neurological disease worldwide. It is mainly characterized by an electrical abnormal activity in different brain regions. The massive entrance of Ca2+ into neurons is the main neurotoxic process that lead to cell death and finally to neurodegeneration. Although there are a huge number of antiseizure medications, there are many patients who do not respond to the treatments a...
Lipid nanoparticles for the posterior eye segment
Bonilla, Lorena; Espina, Marta; Severino, Patricia; Cano, Amanda; Ettcheto, Miren; Camins, Antoni; García, Maria Luisa; Souto, Eliana B.This review highlights the application of lipid nanoparticles (Solid Lipid Nanoparticles, Nanostructured Lipid Carriers, or Lipid Drug Conjugates) as effective drug carriers for pathologies affecting the posterior ocular segment. Eye anatomy and the most relevant diseases affecting the posterior segment will be summarized. Moreover, preparation methods and different types and subtypes of lipid nanoparticles wil...
Biodegradable nanoparticles for the treatment of epilepsy: from current advance...
Bonilla, Lorena; Esteruelas, Gerard; Ettcheto, Miren; Espina, Marta; García, María Luisa; Camins, Antoni; Souto, Eliana B.; Cano, AmandaEpilepsy is the second most prevalent neurological disease worldwide. It is mainly characterized by an electrical abnormal activity in different brain regions. The massive entrance of Ca2+ into neurons is the main neurotoxic process that lead to cell death and finally to neurodegeneration. Although there are a huge number of antiseizure medications, there are many patients who do not respond to the treatments a...
Nanomedicine-based technologies and novel biomarkers for the diagnosis and trea...
Cano, Amanda; Turowski, Patric; Ettcheto, Miren; Duskey, Jason Thomas; Tosi, Giovanni; Sánchez-López, Elena; García, Maria Luisa; Camins, AntonioIncreasing life expectancy has led to an aging population, which has consequently increased the prevalence of dementia. Alzheimer's disease (AD), the most common form of dementia worldwide, is estimated to make up 50-80% of all cases. AD cases are expected to reach 131 million by 2050, and this increasing prevalence will critically burden economies and health systems in the next decades. There is currently no t...
Epilepsy in Neurodegenerative Diseases: Related Drugs and Molecular Pathways
Cano, Amanda; Fonseca, Elena; Ettcheto, Miren; Sánchez-López, Elena; de Rojas, Itziar; Alonso-Lana, Silvia; Morató, Xavier; Souto, Eliana B.Epilepsy is a chronic disease of the central nervous system characterized by an electrical imbalance in neurons. It is the second most prevalent neurological disease, with 50 million people affected around the world, and 30% of all epilepsies do not respond to available treatments. Currently, the main hypothesis about the molecular processes that trigger epileptic seizures and promote the neurotoxic effects tha...
State of the Art on Toxicological Mechanisms of Metal and Metal Oxide Nanoparti...
García-Torra, Victor; Cano, Amanda; Espina, Marta; Ettcheto, Miren; Camins, Antoni; Barroso, Emma; Vazquez-Carrera, Manel; García, Maria LuisaMetal nanoparticles have been extensively investigated for different types of pharmaceutical applications. However, their use has raised some concerns about their toxicity involving the increase of reactive oxygen species causing cellular apoptosis. Therefore, in this review we summarize the most relevant toxicity mechanisms of gold, silver, copper and copper oxide nanoparticles as well as production methods of...
Surface Functionalization of PLGA Nanoparticles to Increase Transport across th...
Del Amo, Laura; Cano, Amanda; Ettcheto, Miren; Souto, Eliana B.; Espina, Marta; Camins, Antoni; García, Maria Luísa; Sánchez-López, ElenaAlzheimer’s disease (AD) is a chronic neurodegenerative disorder that accounts for about 60% of all diagnosed cases of dementia worldwide. Although there are currently several drugs marketed for its treatment, none are capable of slowing down or stopping the progression of AD. The role of the blood-brain barrier (BBB) plays a key role in the design of a successful treatment for this neurodegenerative disease. N...
Surface functionalization of PLGA nanoparticles to increase transport across th...
Del Amo, Laura; Cano, Amanda; Ettcheto, Miren; Souto, Eliana B.; Espina, Marta; Camins, Antoni; García, Maria Luísa; Sánchez-López, ElenaAlzheimers disease (AD) is a chronic neurodegenerative disorder that accounts for about 60% of all diagnosed cases of dementia worldwide. Although there are currently several drugs marketed for its treatment, none are capable of slowing down or stopping the progression of AD. The role of the blood-brain barrier (BBB) plays a key role in the design of a successful treatment for this neurodegenerative disease. Na...
Epilepsy in neurodegenerative diseases: related drugs and molecular pathways
Cano, Amanda; Fonseca, Elena; Ettcheto, Miren; Sánchez-López, Elena; de Rojas, Itziar; Alonso-Lana, Silvia; Morató, Xavier; Souto, Eliana B.Epilepsy is a chronic disease of the central nervous system characterized by an electrical imbalance in neurons. It is the second most prevalent neurological disease, with 50 million people affected around the world, and 30% of all epilepsies do not respond to available treatments. Currently, the main hypothesis about the molecular processes that trigger epileptic seizures and promote the neurotoxic effects tha...