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Pyruvate dehydrogenase deficiency

Silva, Maria Joao; Pinheiro, Ana; Eusebio, Filomena; Gaspar, Ana; de Almeida, Isabel Tavares; Rivera, Isabel

The pyruvate dehydrogenase complex (PDHc) is an intramitochondrial multienzyme system, which plays a key role in aerobic glucose metabolism by catalysing the oxidative decarboxylation of pyruvate to acetyl-CoA. Genetic defects in the PDHc lead to lactic a

Date: 2009   |   Origin: Repositório da Universidade de Lisboa
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