11 documents found, page 1 of 2
Comprehensive molecular landscape of cetuximab resistance in head and neck canc...
Gomes, Izabela N. F.; Silva-Oliveira, Renato J. da; Silva, Luciane Sussuchi da; Martinho, Olga; Evangelista, Adriane F.; Helvoort Lengert, André vanCetuximab is the sole anti-EGFR monoclonal antibody that is FDA approved to treat head and neck squamous cell carcinoma (HNSCC). However, no predictive biomarkers of cetuximab response are known for HNSCC. Herein, we address the molecular mechanisms underlying cetuximab resistance in an in vitro model. We established a cetuximab resistant model (FaDu), using increased cetuximab concentrations for more than eigh...
The role of single-nucleotide polymorphism (SNPs) in toxicity of induction chem...
De Marchi, Pedro; Melendez, Matias E.; Laus, Ana C.; Kuhlmann, Pamela A.; de Carvalho, Ana Carolina; Arantes, Lidia Maria R.B.; Evangelista, Adriane F.Made available in DSpace on 2022-04-28T19:27:47Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-11-01; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Background: Induction chemotherapy in locally-advanced head and neck squamous cell carcinoma (LAHNSCC) patients is potentially associated to serious adverse events. Biomarkers associated with toxicity could tailor its indication. This...
Deregulated micrornas are associated with patient survival and predicted to tar...
Souza, Cristiano P. [UNESP]; Cinegaglia, Naiara C. [UNESP]; Felix, Tainara F. [UNESP]; Evangelista, Adriane F.; Oliveira, Rogério A. [UNESP]Made available in DSpace on 2021-06-25T10:34:31Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-09-01; Financiadora de Estudos e Projetos; (1) Background: Although the advances in diagnostic and treatment strategies, lung cancer remains the leading cause of cancer-related deaths, worldwide, with survival rates as low as 16% in developed countries. Low survival rates are mainly due to late diagnosis and t...
Identification of Cell-Free Circulating MicroRNAs for the Detection of Early Br...
Souza, Karen C. B.; Evangelista, Adriane F.; Leal, Letícia F.; Souza, Cristiano P.; Vieira, René A.; Causin, Rhafaela L.; Neuber, A. C.Early detection is crucial for achieving a reduction in breast cancer mortality. Analysis of circulating cell-free microRNAs present in the serum of cancer patients has emerged as a promising new noninvasive biomarker for early detection of tumors and for predicting their molecular classifications. The rationale for this study was to identify subtype-specific molecular profiles of cell-free microRNAs for early ...
Euphol, a tetracyclic triterpene, from Euphorbia tirucalli induces autophagy an...
Silva, Viviane A. O.; Rosa, Marcela N.; Miranda-Gonçalves, Vera; Costa, Ângela Margarida Amorim; Tansini, Aline; Evangelista, Adriane F.; Martinho, OlgaGlioblastoma (GBM) is the most frequent and aggressive type of brain tumor. There are limited therapeutic options for GBM so that new and effective agents are urgently needed. Euphol is a tetracyclic triterpene alcohol, and it is the main constituent of the sap of the medicinal plant Euphorbia tirucalli. We previously identified anti-cancer activity in euphol based on the cytotoxicity screening of 73 human canc...
Expression of tumor suppressors miR-195 and let-7a as potential biomarkers of i...
Marques, Marcia M.; Evangelista, Adriane F.; Macedo, Taciane; Vieira, Rene Aloisio da Costa; Scapulatempo-Neto, Cristovam; Reis, Rui M.OBJECTIVE: MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at the posttranscriptional level. Some miRNAs, including let-7a and miR-195, have been described as tumor suppressors. However, the roles of these microRNAs in breast cancer progression remain controversial. The aim of this study is to evaluate miR-195 and let-7a expression as potential biomarkers of invasive breast cancer. ME...
Expression of tumor suppressors miR-195 and let-7a as potential biomarkers of i...
Marques, Marcia M.; Evangelista, Adriane F.; Macedo, Taciane; Vieira, René Aloisio da Costa; Scapulatempo-Neto, Cristovam; Reis, R. M.MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at the posttranscriptional level. Some miRNAs, including let-7a and miR-195, have been described as tumor suppressors. However, the roles of these microRNAs in breast cancer progression remain controversial. The aim of this study is to evaluate miR-195 and let-7a expression as potential biomarkers of invasive breast cancer.
Reproducibility of the NanoString 22-gene molecular subgroup assay for improved...
Leal, Letícia F.; Evangelista, Adriane F.; Paula, Flávia E. de; Almeida, Gisele Caravina; Carloni, Adriana C.; Saggioro, Fabiano; Stavale, João N.Medulloblastoma is the most frequent malignant brain tumor in children. Four medulloblastoma molecular subgroups, MBSHH , MBWNT , MBGRP3 and MBGRP4 , have been identified by integrated high-throughput platforms. Recently, a 22-gene panel NanoString-based assay was developed for medulloblastoma molecular subgrouping, but the robustness of this assay has not been widely evaluated. Mutations in the gene for human ...
Detection of ALK fusion transcripts in FFPE lung cancer samples by NanoString t...
Evangelista, Adriane F.; Zanon, Maicon F.; Carloni, Adriana C.; Paula, Flávia Escremim de; Morini, Mariana Andozia; Ferreira-Neto, MaressaBackground: ALK-rearranged lung cancers exhibit specific pathologic and clinical features and are responsive to anti-ALK therapies. Therefore, the detection of ALK-rearrangement is fundamental for personalized lung cancer therapy. Recently, new molecular techniques, such as NanoString nCounter, have been developed to detect ALK fusions with more accuracy and sensitivity. Methods: In the present study, we intend...
MicroRNA profiling in human breast cancer cell lines exposed to the anti-neopla...
Bordinhão, A. L. R.; Evangelista, Adriane F.; Oliveira, R. J. S.; Macedo, Taciane; Silveira, Henrique C. S.; Reis, R. M.; Marques, Marcia M. C.Cediranib, a pan-tyrosine kinase inhibitor is showing promising results for the treatment of several solid tumours. In breast cancer, its effects remain unclear, and there are no predictive biomarkers. Several studies have examined the expression profiles of microRNAs (miRNAs) in response to different chemotherapy treatments and found that the expression patterns may be associated with the treatment response. T...