Screening plays a key role in secondary prevention of cervical cancer. High-risk human papillomavirus (hrHPV) testing, a highly sensitive test but with limited specificity, has become the gold standard frontline for screening programs. Thus, the importance of effective triage strategies, including DNA methylation markers, has been emphasized. Despite the potential reported in individual studies, methylation mar...
Bladder cancer (BlCa), specifically urothelial carcinomas, is a heterogeneous disease that derives from the urothelial lining. Two main classes of BlCa are acknowledged: the non-muscle invasive BlCa and the muscle-invasive BlCa; the latter constituting an aggressive disease which invades locally and metastasizes systemically. Distinguishing the specific microenvironment that cancer cells experience between muco...
The Ser/Thr-protein phosphatase PP1 (PP1) is a positive regulator of the androgen receptor (AR), which suggests major roles for PP1 in prostate carcinogenesis. However, studies dedicated to the characterization of PP1 in PCa are currently scarce. Here we analyzed the expression and localization of the PP1 catalytic (PP1c) isoforms in formalin-fixed, paraffin-embedded prostate tissue samples, as well as in PCa c...
Brochura de sala do concerto realizado pelos Jovens Solistas da Metropolitana a 29 de Maio de 2021 no MUSEU NACIONAL da MÚSICA em Lisboa no âmbito da Temporada 2020/2021 da Metropolitana. O programa do concerto foi preenchido com obras de Debussy, Stravinsky, Cuninghame, Mozart e Bottesini. Desenvolvendo uma ponte pedagógica inédita entre a prática e o ensino musical, a ANSO é a única escola do país que forma m...
Brochura de sala do concerto realizado pelos Jovens Solistas da Metropolitana a 16 de Maio de 2021 no Auditório da Biblioteca Orlando Ribeiro em Lisboa no âmbito da Temporada 2020/2021 da Metropolitana. O programa do concerto foi preenchido com obras de Arnold, Bliss, Poradowski, Lopes e Schostakovitch. Desenvolvendo uma ponte pedagógica inédita entre a prática e o ensino musical, a ANSO é a única escola do paí...
Liquid biopsies constitute a minimally invasive means of managing cancer patients, entailing early diagnosis, follow-up and prediction of response to therapy. Their use in the germ cell tumor field is invaluable since diagnostic tissue biopsies (which are invasive) are often not performed, and therefore only a presumptive diagnosis can be made, confirmed upon examination of the surgical specimen. Herein, we pro...
The protein quality control network, including autophagy, the proteasome and the unfolded protein response (UPR), is triggered by stress and is overactive in acquired antiestrogen therapy resistance. We show for the first time that the aggresome load correlates with apoptosis and is increased in antiestrogen-sensitive cells compared to endocrine-resistant variants. LC-MS/MS analysis of the aggregated proteins o...
Como nos conta Aquilino Ribeiro na sua obra Os Avós de Nossos Avós para o romano, o mundo dos prodïqlos ficava a ocidente.Esta tradição ancorada nos interstícios da memória, descia dos longes, no conduto dos escritores gregos, escorada em Platão, o qual recolhera no Egipto o luzeiro esplendoroso de um velho sacerdote de Sais, que, alçado aos portelinhos de múltiplos saberes, lia nas fundas trevas do passado com...
Como nos conta Aquilino Ribeiro na sua obra Os Avós de Nossos Avós para o romano, o mundo dos prodïqlos ficava a ocidente.Esta tradição ancorada nos interstícios da memória, descia dos longes, no conduto dos escritores gregos, escorada em Platão, o qual recolhera no Egipto o luzeiro esplendoroso de um velho sacerdote de Sais, que, alçado aos portelinhos de múltiplos saberes, lia nas fundas trevas do passado com...