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Calcium Phosphate Carrying Simvastatin Enhances Bone Regeneration: A Systematic...
Cruz,Rebecca; Pesce,Giovanna; Calasans-Maia,José; Moraschini,Vittorio; Calasans-Maia,Monica Diuana; Granjeiro,José MauroAbstract Several studies have aimed to develop alternative therapeutic biomaterials for bone repair. The purpose of this systematic review was to evaluate how statins carried by calcium phosphate affect the formation and regeneration of bone tissue in animal models when compared to other biomaterials or spontaneous healing. This systematic review followed the recommendations of the Cochrane Handbook for Systema...
Method to Determine the Root Canal Anatomic Dimension by using a New Cone-Beam ...
Bueno,Mike R; Estrela,Cyntia R.A.; Granjeiro,José Mauro; Sousa-Neto,Manoel D.; Estrela,CarlosAbstract This study discusses a method to determine the root canal anatomic dimension by using e-Vol DX software. The methodology consists in initially establishes the correct positions which will be measured, define the point on the edge of the anatomical structure, and next adjust the intermediate position in the grayscale of CBCT image. Afterward, thin sections (0.10 mm) are obtained from 3D reconstructed sl...
Chronic Periodontitis and RANKL/OPG Ratio in Peri-Implant Mucosae Inflammation
Costa,Lucas Carneiro; Fonseca,Marcos Alexandre da; Pinheiro,Aristides da Rosa; Aguiar,Telma Regina da Silva; Machado,Aldir NascimentoAbstract tHistory of chronic periodontitis (CP) is a risk factor for oseointegration failure. The osteoclastogenesis system (RANK, RANKL and OPG) is critical for bone homeostatic control. We investigated the levels of OPG and RANKL in peri-implant tissues from volunteers with and without a history of CP and their association with mucosae inflammation. This is a single-blind case-contro study. Diagnosis of a his...
In Vitro and In Vivo Biocompatibility Of ReOss® in Powder and Putty Configurations
Pintor,Andréa Vaz Braga; Resende,Rodrigo Figueiredo de Brito; Neves,Adriana Terezinha Novelino; Alves,Gutemberg Gomes; Coelho,Paulo G.Article This study evaluated comparatively two configurations (powder and putty) of a composite biomaterial based on PLGA (Poly(lactide-co-glycolide)/nanoescale hydroxyapatite (ReOss®, Intra-Lock International) through microscopic morphology, in vitro cytotoxicity, biocompatibility and in vivo response as a bone substitute. SEM and EDS characterized the biomaterials before/after grafting. Cytocompatibility was ...
Alveolar bone repair with strontium- containing nanostructured carbonated hydro...
Carmo,André Boziki Xavier do; Sartoretto,Suelen Cristina; Alves,Adriana Terezinha Neves Novellino; Granjeiro,José Mauro; Miguel,Fúlvio BorgesABSTRACT Objective: This study aimed to evaluate bone repair in rat dental sockets after implanting nanostructured carbonated hydroxyapatite/sodium alginate (CHA) and nanostructured carbonated hydroxyapatite/sodium alginate containing 5% strontium microspheres (SrCHA) as bone substitute materials. Methods: Twenty male Wistar rats were randomly divided into two experimental groups: CHA and SrCHA (n=5/period/grou...
Assessing the association between hypoxia during craniofacial development and o...
Küchler,Erika Calvano; Silva,Lea Assed da; Nelson-Filho,Paulo; Sabóia,Ticiana M.; Rentschler,Angela M.; Granjeiro,José Mauro; Oliveira,DrielyAbstract Objectives To evaluate the association between hypoxia during embryo development and oral clefts in an animal model, and to evaluate the association between polymorphisms in the HIF-1A gene with oral clefts in human families. Material and Methods The study with the animal model used zebrafish embryos at 8 hours post-fertilization submitted to 30% and 50% hypoxia for 24 hours. At 5 days post-fertilizati...
Genetic Polymorphism in MMP9 May Be Associated With Anterior Open Bite in Children
Küchler,Erika Calvano; Barreiros,Driely; Silva,Raphaela Oliveira da; Abreu,Júlia Guimarães Barcellos de; Teixeira,Ellen CardosoAbstract Anterior open bite (AOB) has a multifactorial etiology caused by the interaction of sucking habits and genetic factors. The aim of this study was to evaluate the association between AOB and polymorphisms in genes that encode Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs). Four hundred and seventy-two children that presented at least one sucking habit were evaluated. Children were ...
Accelerated Healing Period with Hydrophilic Implant Placed in Sheep Tibia
Sartoretto,Suelen Cristina; Calasans-Maia,José de Albuquerque; Costa,Yanan Osório da; Louro,Rafael Seabra; Granjeiro,José MauroAbstract The objective of this study was to evaluate the early osseointegration of two different implants surfaces, a sandblasted and acid-etched surface (TN) compared with same geometry and surface roughness modified to be hydrophilic/wettable by conditioning in an isotonic solution of 0.9% sodium-chloride (TA) through histological and histomorphometric analysis after sheep tibia implantation. Forty dental imp...
MMP13, TIMP2 and TGFB3 Gene Polymorphisms in Brazilian Chronic Periodontitis an...
Gonçalves Junior,Roberto; Pinheiro,Aristides da Rosa; Schoichet,José Jorge; Nunes,Carlos Henrique Ramirez; Gonçalves,Rackel; Bonato,Leticia LadeiraAbstract Subjects susceptible to chronic periodontitis (CP) show a high risk for the development of peiimplantitis (PI). Both diseases are multifactorial, presenting similarities in their pathophysiology and polygenic profile. MMP-13 (matrix metalloproteinases 13/ collagenase 3) is a collagenolytic enzyme, which expression is induced by TGF beta 3 (transforming growth factor type 3) in human gingival fibroblast...
Haplotypes in BMP4 and FGF Genes Increase the Risk of Peri-Implantitis
Coelho,Renata Barboza; Gonçalves Junior,Roberto; Villas-Boas,Ricardo de Mello; Bonato,Leticia Ladeira; Quinelato,Valquiria; Pinheiro,Aristides da RosaAbstract Despite the success of osseointegrated implants, failures have increased significantly, associated with development of peri-implantitis. Multiple factors influence the peri-implant bone loss, including environmental and genetic causes. BMPs (Bone morphogenetic proteins) are growth factors that induce bone formation. FGF (fibroblast growth factors) and their receptors (FGFRs) play important roles by con...