22 documents found, page 1 of 3
The Debate between the Human Microbiota and Immune System in Treating Aerodiges...
Domingues, Cátia; Cabral, Cristiana Isabel Lima; Jarak, Ivana; Veiga, Francisco; Dourado, Marília; Figueiras, AnaThe human microbiota comprises a group of microorganisms co-existing in the human body. Unbalanced microbiota homeostasis may impact metabolic and immune system regulation, shrinking the edge between health and disease. Recently, the microbiota has been considered a prominent extrinsic/intrinsic element of cancer development and a promising milestone in the modulation of conventional cancer treatments. Particul...
The Role of Cyclodextrins in COVID-19 Therapy-A Literature Review
Almeida, Beatriz C.; Domingues, Cátia; Mascarenhas-Melo, Filipa; Silva, Inês; Jarak, Ivana; Veiga, Francisco; Figueiras, AnaCoronavirus disease-19 (COVID-19) emerged in December 2019 and quickly spread, giving rise to a pandemic crisis. Therefore, it triggered tireless efforts to identify the mechanisms of the disease, how to prevent and treat it, and to limit and hamper its global dissemination. Considering the above, the search for prophylactic approaches has led to a revolution in the reglementary pharmaceutical pipeline, with th...
Pediatric Drug Development: Reviewing Challenges and Opportunities by Tracking ...
Domingues, Cátia; Jarak, Ivana; Veiga, Francisco; Dourado, Marília; Figueiras, AnaThe paradigm of pediatric drug development has been evolving in a "carrot-and-stick"-based tactic to address population-specific issues. However, the off-label prescription of adult medicines to pediatric patients remains a feature of clinical practice, which may compromise the age-appropriate evaluation of treatments. Therefore, the United States and the European Pediatric Formulation Initiative have recommend...
Primary Metabolite Screening Shows Significant Differences between Embryogenic ...
Caeiro, André; Jarak, Ivana; Correia, Sandra; Canhoto, Jorge; Carvalho, RuiTamarillo is a solanaceous tree that has been extensively studied in terms of in vitro clonal propagation, namely somatic embryogenesis. In this work, a protocol of indirect somatic embryogenesis was applied to obtain embryogenic and non-embryogenic callus from leaf segments. Nuclear magnetic resonance spectroscopy was used to analyze the primary metabolome of these distinct calli to elucidate possible differen...
Exenatide and Dapagliflozin Combination Enhances Sertoli Cell Secretion of Key ...
Ribeiro, João C.; Martins, Ana D.; Jarak, Ivana; Carvalho, Rui A.; Alves, Marco G.; Oliveira, Pedro F.The incidence of metabolic diseases such as type 2 diabetes mellitus (DM) and obesity has been increasing dramatically. Both diseases are closely linked and new approaches for type 2 DM treatment aim to enable weight loss. A combined therapy of dapagliflozin and exenatide has been used against type 2 DM, influencing allbody glucose dynamics. Spermatogenesis is highly dependent on the metabolic cooperation estab...
New Advances in Biomedical Application of Polymeric Micelles
Figueiras, Ana; Domingues, Cátia; Jarak, Ivana; Santos, Ana Isabel; Parra, Ana; Pais, Alberto; Alvarez-Lorenzo, Carmen; Concheiro, AngelAbstract In the last decade, nanomedicine has arisen as an emergent area of medicine, which studies nanometric systems, namely polymeric micelles (PMs), that increase the solubility and the stability of the encapsulated drugs. Furthermore, their application in dermal drug delivery is also relevant. PMs present unique characteristics because of their unique core-shell architecture. They are colloidal dispersions...
Polymeric Micelles: A Promising Pathway for Dermal Drug Delivery
Parra, Ana; Jarak, Ivana; Santos, Ana; Veiga, Francisco; Figueiras, Ana RitaNanotechnology is an area in great development and with application in the most varied fields of science, including cosmetic and pharmaceutical industries. Because conventional formulations for topical application are not always able to effectively penetrate the physical barrier that human skin exerts against factors and compounds of the external environment, polymeric micelles appear as alternative carriers fo...
Chenodeoxycholic Acid Has Non-Thermogenic, Mitodynamic Anti-Obesity Effects in ...
Teodoro, João S.; Machado, Ivo F.; Castela, Ana C.; Amorim, João A.; Jarak, Ivana; Carvalho, Rui A.; Palmeira, Carlos M.; Rolo, Anabela P.Bile acids (BA) have shown promising effects in animal models of obesity. However, the said effects are thought to rely on a thermogenic effect, which is questionably present in humans. A previous work has shown that the BA chenodeoxycholic acid (CDCA) can revert obesity and accelerate metabolism in animal and cell culture models. Thus, the aim of this study was to understand if this obesity reduction is indeed...
Blueberry Counteracts Prediabetes in a Hypercaloric Diet-Induced Rat Model and ...
Nunes, Sara; Viana, Sofia D.; Preguiça, Inês; Alves, André; Fernandes, Rosa; Teodoro, João S.; Matos, Patrícia; Figueirinha, Artur; Salgueiro, LígiaThe paramount importance of a healthy diet in the prevention of type 2 diabetes is now well recognized. Blueberries (BBs) have been described as attractive functional fruits for this purpose. This study aimed to elucidate the cellular and molecular mechanisms pertaining to the protective impact of blueberry juice (BJ) on prediabetes. Using a hypercaloric diet-induced prediabetic rat model, we evaluated the effe...
Inheritable testicular metabolic memory of high-fat diet causes transgeneration...
Crisóstomo, Luís; Jarak, Ivana; Rato, Luís P; Raposo, João F; Batterham, Rachel L; Oliveira, Pedro F.; Alves, Marco GThe consumption of energy-dense diets has contributed to an increase in the prevalence of obesity and its comorbidities worldwide. The adoption of unhealthy feeding habits often occurs at early age, prompting the early onset of metabolic disease with unknown consequences for reproductive function later in life. Recently, evidence has emerged regarding the intergenerational and transgenerational effects of high-...