Encontrados 3 documentos, a visualizar página 1 de 1
Epidemic history and baseline resistance to NS5A-specific direct acting drugs o...
Palladino, Claudia; Ezeonwumelu, Ifeanyi J.; Maté, Irene; Borrego, Pedro; Martínez-Román, Paula; Arca-Lafuente, Sonia; Resino, Salvador; Taveira, NunoHepatitis C virus (HCV) infection remains a global health problem. Previously, the prevalence of NS5A resistance-associated substitutions (RASs) to elbasvir, a new direct-acting antiviral (DAA) against the NS5A viral protein was assessed by our group before its introduction into clinical use in Spain. However, the origin, epidemic history, transmission dynamics, diversity and baseline RASs to NS5A direct-acting...
Accidental father-to-son HIV-1 transmission during the seroconversion period
Ezeonwumelu, Ifeanyi J.; Bártolo, Inês; Martin, Francisco; Abecasis, Ana B.; Campos, Teresa; Romero-Severson, Ethan; Leitner, Thomas; Taveira, NunoA 4-year-old child born to an HIV-1 seronegative mother was diagnosed with HIV-1, the main risk factor being transmission from the child's father who was seroconverting at the time of the child's birth. In the context of a forensic investigation, we aimed to identify the source of infection of the child and date of the transmission event. Samples were collected from the father and child at two time points about...
Epidemic history of hepatitis C virus genotypes and subtypes in Portugal
Palladino, Claudia; Ezeonwumelu, Ifeanyi J.; Marcelino, Rute; Briz, Verónica; Moranguinho, Inês; Serejo, Fátima; Velosa, José Fernando; Marinho, RuiAny successful strategy to prevent and control HCV infection requires an understanding of the epidemic behaviour among the different genotypes. Here, we performed the first characterization of the epidemic history and transmission dynamics of HCV subtypes in Portugal. Direct sequencing of NS5B was performed on 230 direct-acting antiviral drugs (DAA)-treatment naïve patients in Lisbon. Phylogenetic analysis was ...