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Phylogeography of hepatitis B virus: the role of Portugal in the early dissemin...
Marcelino, Rute; Ezeonwumelu, Ifeanyi Jude; Janeiro, André; Mimoso, Paula; Matos, Sónia; Briz, Veronica; Pimentel, Victor; Pingarilho, MartaIn Portugal, the genetic diversity, origin of HBV and the Portuguese role in the dissemination of HBV worldwide were never investigated. In this work, we studied the epidemic history and transmission dynamics of HBV genotypes that are endemic in Portugal. HBV pol gene was sequenced from 130 patients followed in Lisbon. HBV genotype A was the most prevalent (n = 54, 41.5%), followed by D (n = 44, 33.8%), and E (...
Phylogeography of hepatitis B virus : the role of Portugal in the early dissemi...
Marcelino, Rute; Ezeonwumelu, Ifeanyi Jude; Janeiro, André; Mimoso, Paula; Matos, Sónia; Briz, Veronica; Pimentel, Victor; Pingarilho, MartaIn Portugal, the genetic diversity, origin of HBV and the Portuguese role in the dissemination of HBV worldwide were never investigated. In this work, we studied the epidemic history and transmission dynamics of HBV genotypes that are endemic in Portugal. HBV pol gene was sequenced from 130 patients followed in Lisbon. HBV genotype A was the most prevalent (n = 54, 41.5%), followed by D (n = 44, 33.8%), and E (...
Epidemic history and baseline resistance to NS5A-specific direct acting drugs o...
Palladino, Claudia; Ezeonwumelu, Ifeanyi Jude; Mate-Cano, Irene; Borrego, Pedro; Martínez-Román, Paula; Arca-Lafuente, Sonia; Resino, SalvadorHepatitis C virus (HCV) infection remains a global health problem. Previously, the prevalence of NS5A resistance-associated substitutions (RASs) to elbasvir, a new direct-acting antiviral (DAA) against the NS5A viral protein was assessed by our group before its introduction into clinical use in Spain. However, the origin, epidemic history, transmission dynamics, diversity and baseline RASs to NS5A direct-acting...
Epidemic history of hepatitis C virus genotypes and subtypes in Portugal
Palladino, Claudia; Ezeonwumelu, Ifeanyi Jude; Marcelino, Rute; Briz, Verónica; Moranguinho, Inês; Serejo, Fátima; Velosa, José FernandoAny successful strategy to prevent and control HCV infection requires an understanding of the epidemic behaviour among the different genotypes. Here, we performed the first characterization of the epidemic history and transmission dynamics of HCV subtypes in Portugal. Direct sequencing of NS5B was performed on 230 direct-acting antiviral drugs (DAA)-treatment naïve patients in Lisbon. Phylogenetic analysis was ...