2 documents found, page 1 of 1
Synthesis, in vitro and in vivo anti-Trypanosoma cruzi and toxicological activi...
Almeida, Tamires Cunha; Ribeiro, Luis Henrique Gonzaga; Santos, Luiza Braga Ferreira dos; Silva, Cleiton Moreira da; Branquinho, Renata TupinambáChagas disease is a major health problem not only in Latin America but also in Europe and North America due to the spread of this disease into nonendemic areas. In terms of global burden, this major tropical infection is considered to be one of the most neglected diseases, and there are currently only two available chemotherapies: benznidazole and nifurtimox. Unfortunately, although these chemotherapies are ben...
Calix[n]arene-catalyzed three-component povarov reaction: microwave-assisted sy...
Abranches, Paula Aline da Silva; Paiva, Walysson Ferreira de; Fátima, Angelo de; Martins, Felipe Terra; Fernandes, Sergio AntonioA new one-pot cascade reaction-based application of Povarov reactions with a p-sulfonic acid calix[4]arene catalyst for the synthesis of a series of 34 julolidine derivatives with substituents at C8 or C9 in good to excellent yields is reported. These microwave-assisted reactions proceeded efficiently, had short reaction times, were metal-free, were low cost, and used an inexpensive, easily available and nontox...