5 documents found, page 1 of 1
Uncovering the Early Events Associated with Oligomeric Aβ-Induced Src Activation
Mota, Sandra; Fão, Lígia; Coelho, Patrícia Silva; Rego, A. CristinaSoluble Aβ1-42 oligomers (AβO) are formed in the early stages of Alzheimer's disease (AD) and were previously shown to trigger enhanced Ca2+ levels and mitochondrial dysfunction via the activation of N-methyl-D-aspartate receptors (NMDAR). Src kinase is a ubiquitous redox-sensitive non-receptor tyrosine kinase involved in the regulation of several cellular processes, which was demonstrated to have a reciprocal ...
Macroautophagy and Mitophagy in Neurodegenerative Disorders: Focus on Therapeut...
Magalhães, João Duarte; Fão, Lígia; Vilaça, Rita; Cardoso, Sandra Morais; Rego, A. CristinaMacroautophagy, a quality control mechanism, is an evolutionarily conserved pathway of lysosomal degradation of protein aggregates, pathogens, and damaged organelles. As part of its vital homeostatic role, macroautophagy deregulation is associated with various human disorders, including neurodegenerative diseases. There are several lines of evidence that associate protein misfolding and mitochondrial dysfunctio...
Neuronal cell-based high-throughput screen for enhancers of mitochondrial funct...
Naia, Luana Carvalho; Pinho, Catarina M.; Dentoni, Giacomo; Liu, Jianping; Leal, Nuno Santos; Ferreira, Duarte M. S.; Schreiner, BernadetteBackground: Mitochondrial dysfunction is a common feature of aging, neurodegeneration, and metabolic diseases. Hence, mitotherapeutics may be valuable disease modifiers for a large number of conditions. In this study, we have set up a large-scale screening platform for mitochondrial-based modulators with promising therapeutic potential. Results: Using differentiated human neuroblastoma cells, we screened 1200 F...
Mitochondrial and redox-based therapeutic strategies in Huntington's disease
Fão, Lígia; Rego, Ana CristinaSignificance: The molecular processes that determine Huntington's disease (HD) pathogenesis are not yet fully understood, and until now no effective neuroprotective therapeutic strategies have been developed. Mitochondria are one of most important organelles required for neuronal homeostasis, by providing metabolic pathways relevant for energy production, regulating calcium homeostasis, or controlling free radi...
Shaping the Nrf2-ARE-related pathways in Alzheimer's and Parkinson's diseases
Fão, Lígia; Mota, Sandra; Rego, Ana CristinaA failure in redox homeostasis is a common hallmark of Alzheimer's Disease (AD) and Parkinson's Disease (PD), two age-dependent neurodegenerative disorders (NDD), causing increased oxidative stress, oxidized/damaged biomolecules, altered neuronal function and consequent cell death. Activation of nuclear factor erythroid 2-related factor 2 (Nrf2), a redox-regulated transcription factor, results in upregulation o...