3 documents found, page 1 of 1
Genetic Background and Expression of the New qepA4 Gene Variant Recovered in Cl...
Manageiro, Vera; Félix, David; Jones-Dias, Daniela; Sampaio, Daniel A; Vieira, Luís; Sancho, Luísa; Ferreira, Eugénia; Caniça, ManuelaA new QepA4 variant was detected in an O86:H28 ST156-fimH38 Escherichia coli, showing a multidrug-resistance phenotype. PAβN inhibition ofqepA4-harboring transconjugant resulted in increase of nalidixic acid accumulation. TheqepA4andcatA1genes were clustered in a 26.0-kp contig matching an IncF-type plasmid, and containing a Tn21-type transposon with multiple mobile genetic elements. This QepA variant is worris...
Identification of the new variant QepA3, a plasmid-mediated quinolone resistanc...
Caniça, Manuela; Manageiro, Vera; Jones-Dias, Daniela; Félix, David; Ferreira, EugéniaObjectives: The efflux pump QepA confers decreased susceptibility to hydrophilic fluoroquinolones (e.g., norfloxacin, ciprofloxacin, and enrofloxacin). In this study, we characterized the third variant, named qepA3, collected from an Escherichia coli isolate in Portugal. Methods: INSRA6015 was isolated in 2005 from the urine of a 77-year-old female patient hospitalized at the Hospital Fernando Fonseca, Portugal...
Identification of the new variant QepA3, a plasmid-mediated quinolone resistanc...
Caniça, Manuela; Manageiro, Vera; Jones-Dias, Daniela; Félix, David; Ferreira, EugéniaThe efflux pump QepA confers decreased susceptibility to hydrophilic fluoroquinolones (e.g., norfloxacin, ciprofloxacin, and enrofloxacin). In this study, we characterized the third variant, named qepA3, collected from an Escherichia coli isolate in Portugal. INSRA6015 was isolated in 2005 from the urine of a 77-year-old female patient hospitalized at the Hospital Fernando Fonseca, Portugal. Susceptibility test...