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Immunotherapy in lung cancer brain metastases
Paisana, Eunice; Cascao, Rita; Alvoeiro, Magda; Félix, Francisco; Martins, Guilherme; Guerreiro, Carla; Roque, Rafael; Cruz, Rafael Moiteiro DaBrain metastases (BM) occur frequently in lung cancer, particularly in non-small cell lung cancer (NSCLC) patients and remain a significant cause of morbidity and mortality. Standard therapies have limited efficacy due to poor crossing of the blood-brain barrier and the distinct features between BM and the primary tumor. This review explores the immune landscape of brain metastatic disease, emerging immunothera...
Hot Topic In Thoracic Surgery: Can Sublobar Anatomical Resections Be Non-Inferi...
Nawojowska, Agata; Mendes, Samuel; Cabral, Daniel; Gaspar, Marion Emma; Rodrigues, Cristina; Antunes, Mariana; Alvoeiro, Magda; Calado, TelmaBackground: Technological advances and widely spread screening programs enabled the discovery of ever smaller lesions. As such, in the last years, the tendency has shifted towards lung-sparing procedures. The role of limited surgical excision for small peripheral nodules is currently a topic of heated debate. Aim: In our work, we try to answer whether the segmentectomy could adequately treat the peripheral NSCL...
Successful Radical Resection Of Masaoka Iii Squamous Cell Thymic Carcinoma Inva...
Nawojowska, Ágata; Cabral, Daniel; Neves, José; Félix, FranciscoIntroduction: Complete radical resection is crucial for successfully treating thymic carcinomas. However, when the invasion of the great vessels or the heart in Masaoka III and IV stages occurs, the management poses more challenges. The R0 resection often requires neoadjuvant treatment. We present an example of a debatable case in which a treatment decision was guided by an imminent risk to the patient's life. ...
Oncological Outcomes Of Radical Surgery With And Without Induction And Adjuvant...
Nawojowska, Agata; Mendes, Samuel; Gaspar, Marion; Cabral, Daniel; Rodrigues, Cristina; Antunes, Mariana; Alvoeiro, Magda; Calado, TelmaIntroduction: Mesothelioma is a devastating, insidious disease with a long latency period. Its peak incidence occurs in the 5th and 6th decades of life, up to 40 years after asbestos exposure which is strongly related to the disease. The optimal treatment is the object of an intense discussion. Aims: The established outcomes were disease-free survival (DFS) and 1-year survival analyzed in the context of neoadju...
Parenchymal-Subcutaneous Fistula without Pneumothorax: A Rare Complication of C...
Nunes, André; Cabral, Daniel; Santos, Fernanda; Félix, Francisco; Froes, FilipeN/A.; N/A.
Innovative 3d-Printed Prosthesis In A Rare Case Of A Huge Mass Of Anterior Thor...
Nawojowska, Ágata; Mendes, Samuel; Cabral, Daniel; Antunes, Mariana; Félix, FranciscoThe need for complete resection of chest wall tumors creates a huge challenge in terms of reconstructing the complex dynamics of the thorax. We are reporting a case of a low-grade fibromyxoid sarcoma (LGFMS) diagnosed in a young male, where the complete resection of the mass, sternum and parcially the pericardium was performed. Subsequently, a composite porous high-density polyethylene StarPore® prosthesis of t...
An Unusual Location for a Lymph Node
Nawojowska, Ágata; Cabral, Daniel; Mendes, Samuel; Antunes, Mariana; Félix, FranciscoWe report a case of a 67-years old non-smoking female diagnosed with hypertension when 24-years-old and complicated with chronic kidney and hypertensive heart diseases. On CT-Chest an incidental discovery of a lesion (16x14x23mm) adjacent to the abdominal aorta was made. Initially suspected to be paraganglioma, a hypothesis which the subsequent MRI did not exclude. Urine analysis showed normal Metanephrine with...
LYMPH NODE UPSTAGING AFTER SURGERY IN PATIENTS WITH NEGATIVE MEDIASTINAL STAGIN...
Cabral, Daniel; Rodrigues, Cristina; Antunes, Mariana; Nawojowska, Agata; Calado, Telma; Torres, Carolina; Alvoeiro, Magda; Mendes, SamuelIntroduction: Mediastinal staging is a hot topic in thoracic oncology. According to the guidelines, and besides other criteria, in the presence of a primary lung cancer with increased mediastinal lymph node uptake on PET-CT, a negative result after lymph node sampling by Endobronchial Ultrasound (EBUS) is not enough to rule out mediastinal lymph node involve- ment, demanding a cervical mediastinoscopy to vouch ...
LUNG RESECTION FOR NON-SMALL-CELL LUNG CANCER - A NEW RISK SCORE TO PREDICT MAJ...
Veiga Oliveira, Paulo; Cabral, Daniel; Antunes, Mariana; Torres, Carolina; Alvoeiro, Magda; Rodrigues, Cristina; Sousa-Uva, Miguel; Félix, FranciscoObjectives: Identify risk factors for major perioperative complications (MPC) after anatomical lung resection for NonSmall-Cell Lung Cancer (NSCLC) and establish a scoring system. Methods: Single center retrospective study of all consecutive patients diagnosed with NSCLC submitted to anatomical lung resection from 2015 to 2019 (N=564). Exclusion criteria: previous lung surgery, concomitant non-lung cancer relat...
DESCENDING NECROTIZING MEDIASTINITIS - A MULTIDISCIPLINARY PATHOLOGY
Nicolau Fernandes, António; Santos, Ana Rita; Félix, Francisco; Luís, LeonelA 23-year-old man presented with fever and cervical swelling. Contrast-enhanced CT-scan with oblique sagittal planes reconstructions with extensive collection with gaseous areas, involving multiple cervical and mediastinal spaces is shown, reflecting a cervical-mediastinal necrotizing fasciitis. Note the circumference to the laryngotracheal axis. He underwent combined surgery by ENT and thoracic surgery and was...