23 documents found, page 1 of 3
Preliminary data on the ecotoxicity effects of the novel synthetic cathinone 3,...
Pérez-Pereira, Ariana; Ribeiro, Ondina; Félix, Luís; Tiritan, Maria; Ribeiro, Cláudia; Carrola, JoãoBackground: The use of synthetic cathinones (SC) for recreational purposes has become increasingly common among young individuals in recent years [1]. As a result, SC have been detected in aquatic environments even at low concentrations (between ng L‒1 to µg L‒1) [2] that can negatively impact freshwater vertebrates [3]. Since SC are designed to affect the nervous system, they could potentially cause unpredicta...
Effects on apoptosis and neurotransmitters after exposure to 3-chloromethcathin...
Ribeiro, Ondina; Félix, Luís; Ribeiro, Cláudia; Soares Carrola, JoãoBackground: Synthetic cathinones are a class of new psychoactive substances (NPS) widely consumed worldwide. Their large-scale production and constant structural modifications lead to the emergence of new NPS every year. 3-Chloromethcathinone (3-CMC) was first identified on the European market in 2014 and is a halogenated and N-alkylated derivative of cathinone [1]. 3-CMC has a chiral centre, giving rise to two...
Aloysia citrodora extract as a chemopreventive agent against HPV16-induced lesi...
Medeiros-Fonseca, Beatriz; Faustino-Rocha, Ana; Silva, Jessica; Silva, Mónica; Pires, Maria João; Neuparth, Maria João; Vala, HelenaAloysia citrodora has a long history of traditional use in treating various ailments. This study evaluated the in vivo chemopreventive efficacy and systemic toxicity of an extract of A. citrodora in a transgenic mouse model of HPV16 (human papillomavirus type 16)-induced cancer. Methods: The experiment involved six groups (n = 5): group 1 (G1, wild-type (WT), water), group 2 (G2, HPV, water), group 3 (G3, WT, 0...
Effects of a Cyperus esculentus L. plant-based beverage on FVB/n female mice
Fernandes, Filipa Alexandra; Oliveira, Paula A.; Pinto, M.L.; Venâncio, Carlos; Félix, Luís; Medeiros-Fonseca, Beatriz; Correia, RossanaThis work evaluated the effects of the consumption of a plant-based beverage (Cyperus esculentus L., Adansonia digitata L., and thermal water) on the physiological parameters of mice over a 28-day period. Thirty-two female FVB/n mice (n = 8) were randomly assigned to one of four groups divided into two experimental protocols: Group 1 drank water and Group 2 drank a plant-based beverage for 24 h; in the second e...
Exploring the therapeutic potential of Quercus ilex acorn extract in papillomav...
Medeiros-Fonseca, Beatriz; Faustino-Rocha, Ana; Pires, Maria João; Neuparth, Maria João; Vala, Helena; Vasconcelos-Nóbrega, Cármen; Gouvinhas, IrenePapillomaviruses (PVs) infections have been documented in numerous animal species across different regions worldwide. They often exert significant impacts on animal health and livestock production. Scientists have studied natural products for over half a century due to their diverse chemical composition, acknowledging their value in fighting cancer. Acorns (Quercus ilex) are believed to have several unexplored ...
Exploring the therapeutic potential of Quercus ilex acorn extract in papillomav...
Medeiros-Fonseca, Beatriz; Faustino-Rocha, Ana I.; Pires, Maria João; Neuparth, Maria João; Vala, Helena; Nóbrega, Carmen; Gouvinhas, IreneBackground and Aim: Papillomaviruses (PVs) infections have been documented in numerous animal species across different regions worldwide. They often exert significant impacts on animal health and livestock production. Scientists have studied natural products for over half a century due to their diverse chemical composition, acknowledging their value in fighting cancer. Acorns (Quercus ilex) are believed to have...
Aloysia citrodora extract as a chemopreventive agent against HPV16-induced lesi...
Medeiros-Fonseca, Beatriz; Faustino-Rocha, Ana I.; Silva, Jéssica; Silva, Mónica G.; Pires, Maria João; Neuparth, Maria João; Vala, HelenaAim: Aloysia citrodora has a long history of traditional use in treating various ailments. This study evaluated the in vivo chemopreventive efficacy and systemic toxicity of an extract of A. citrodora in a transgenic mouse model of HPV16 (human papillomavirus type 16)-induced cancer. Methods: The experiment involved six groups (n = 5): group 1 (G1, wild-type (WT), water), group 2 (G2, HPV, water), group 3 (G3, ...
loysia citrodora extract as a chemopreventive agent against HPV16-induced lesio...
Medeiros-Fonseca, Beatriz; Faustino-Rocha, Ana I; Silva, Jessica; Pires, Maria João; Neuparth, Maria João; Vala, Helena; Vasconcelos-Nóbrega, CarmenAim: Aloysia citrodora has a long history of traditional use in treating various ailments. This study evaluated the in vivo chemopreventive efficacy and systemic toxicity of an extract of A. citrodora in a transgenic mouse model of HPV16 (human papillomavirus type 16)-induced cancer. Methods: The experiment involved six groups (n = 5): group 1 (G1, wild-type (WT), water), group 2 (G2, HPV, water), group 3 (G3, ...
Sublethal enantiotoxicity of MDMA on the development, teratogenicity, genotoxic...
Ribeiro, Ondina; Félix, Luís; Ribeiro, Cláudia; Gonçalves, Virgínia; Tiritan, Maria Elizabeth; Soares Carrola, JoãoBackground: Chiral psychoactive substances (PAS) as amphetamine-like substances are among the main group of drugs seized in Europe. The increased attractiveness of these drugs resulted in their widespread occurrence in the environment raising concern about their possible hazardous effects to non-target organisms [1, 2]. PAS metabolism in humans and biodegradation in wastewater treatment plants is stereosel...
Evaluation of oxidative stress and apoptosis responses in zebrafish (Danio reri...
Ribeiro, Ondina; Félix, Luís; Ribeiro, Cláudia; Tiritan, Maria Elizabeth; Carrola, João SoaresBackground: The emergence of new psychoactive substances (NPS) in the worldwide drug market raises huge concerns over public health, drug policy and environmental adverse effects [1]. Butylone (BTL) is a synthetic chiral cathinone [2] reported in wastewater effluents and despite its increasing presence in freshwater ecosystems, no studies were found on the BTL toxic evaluation in fish, including the well-known ...