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Design racional de fármacos auxiliado por computador com vistas ao direcionamen...
Félix, Mayara BarbalhoChemoinformatics is presented through a range of applications in the field of drug design in order to contribute to the identification of new compounds against a variety of diseases. Among these, leishmaniasis, whose current treatment requires improvement because it has several side effects and does not have the desired efficacy. With this, this study aimed at the planning of new molecules derived from the indo...
Drug discovery and computational strategies in the multitarget drugs era
Viana, Jéssika de Oliveira; Félix, Mayara Barbalho; Maia, Mayarara dos Santos; Serafim, Vanessa de Lima; Scotti, Luciana; Scotti, Marcus TulliusThe pharmaceutical industry is increasingly joining chemoinformatics in the search for the development of new drugs to be used in the treatment of diseases. These computational studies have the advantage of being less expensive and optimize the study time, and thus the interest in this area is increasing. Among the techniques used is the development of multitarget directed ligands (MTDLs), which has become an a...
Desenvolvimento e avaliação biológica de novos derivados 2-amino tiofênicos ind...
Félix, Mayara BarbalhoLeishmaniasis is a group of diseases caused by protozoa of the genus Leishmania, transmitted by insects phlebotomines. The recommended treatments for leishmaniasis are very toxic and unsatisfactory. Therefore, it is urgent to find new anti-Leishmania drugs that are more effective against the parasite and exhibit low toxicity to the host. Thus, this study sought to synthesize, characterize and evaluate the anti-...