51 documents found, page 1 of 6

Optimistic and pessimistic cognitive judgement bias modulates the stress respon...

Cognitive judgement bias in decision-making under ambiguity occurs both in animals and humans, with some individuals interpreting ambiguous stimulus as positive (optimism) and others as negative (pessimism). We hypothesize that judgement bias is a personality trait and that individuals with a pessimistic bias would be more reactive to stressors and therefore more susceptible to stress-related diseases than opti...

Towards a Less Invasive Treatment for Head and Neck Cancer

Background/Objectives: Head and neck cancer (HNC) is the sixth most common cancer worldwide, with a high mortality, particularly from head and neck squamous cell carcinoma (HNSCC). Although some therapeutic strategies are available, they might cause severe side effects. For example, surgery may result in disfigurement and functional loss, severely impacting the patient’s quality of life. Thus, minimally invasiv...

Gold nanoparticles: a promising next-generation tool for breast cancer photothe...

AuNPs show suitable mean sizes and maximum absorbance peaks to be used for PTT when locally administered. AuNPs show no toxicity either in breast cancer cell lines or red blood cells. Laser irradiation proved to be safe when applied alone. Combining EGF-conjugated AuNPs with laser irradiation resulted in a reduction of 33% in MCF-7 cells viability. The animal model was successfully developed (all animals develo...

Exploring canine mast cell tumors: An investigation into demographic characteri...

Mast cell tumors (MCT) are among the most common neoplasia in dogs, representing up to 21 % of skin tumors. However, etiology and risk factors for its development remain unclear. This study aimed to reduce this knowledge gap by comprehensively analyzing 905 MCT cases diagnosed in Portugal between 2019 and 2021, using descriptive and inferential analyses. Most tumors affected the skin, with 69.9 % and 21.2 % cla...

Targeting circulating labile heme as a defense strategy against malaria

Severe presentations of malaria emerge as Plasmodium (P.) spp. parasites invade and lyse red blood cells (RBC), producing extracellular hemoglobin (HB), from which labile heme is released. Here, we tested whether scavenging of extracellular HB and/or labile heme, by haptoglobin (HP) and/or hemopexin (HPX), respectively, counter the pathogenesis of severe presentations of malaria. We found that circulating labil...

A One pathology multicentre Portuguese approach to thyroid tumours of dogs and ...

Thyroid tumours are the most common endocrine tumours of dogs and cats. Feline thyroid tumours are essentially functional adenomas curable with thyroidectomy, whereas most canine thyroid tumours are non-functional carcinomas either unresectable or recurrent within two years in up 50%. The oncobiology of these tumours remains unclear, but investigating this aspect could contribute to the development of targeted ...

Pluronic® F127 Hydrogel Containing Silver Nanoparticles in Skin Burn Regenerati...

Presently, skin burns are considered one of the main public health problems and lack therapeutic options. In recent years, silver nanoparticles (AgNPs) have been widely studied, playing an increasingly important role in wound healing due to their antibacterial activity. This work is focused on the production and characterization of AgNPs loaded in a Pluronic® F127 hydrogel, as well as assessing its antimicrobia...

Passeio pelo saber

Após vários anos de disputa pelo poder entre os países espalhados pelo mundo, nasce uma aliança com o nome de Ciclo Perfeito. Um regime criado por um governo intitulado de Estado. Ficou acordado que os países se uniriam com o propósito de governar juntos o mundo e desta forma controlar a comunidade. As pessoas apenas teriam conhecimento daquilo que eles pretendessem. Inicialmente foi difícil porque as pessoas n...

Contributo ao estudo dos mastocitomas dos cães

Contributo ao estudo dos mastocitomas dos cães

Os mastocitomas são as neoplasias malignas de pele mais comuns nos cães. O diagnóstico é direto, contudo o seu comportamento biológico é imprevisível. Até ao momento continua a não existir uma metodologia capaz de sinalizar todos os mastocitomas mais agressivos. A linha de investigação do nosso laboratório e tema de projeto de doutoramento foca-se na avaliação do potencial prognóstico de diferentes técnicas e m...