6 documents found, page 1 of 1
Botulinum toxin for hereditary spastic paraplegia: effects on motor and non-mot...
Servelhere,Katiane R.; Faber,Ingrid; Martinez,Alberto; Nickel,Renato; Moro,Adriana; Germiniani,Francisco M. B.; Moscovich,Mariana; Blume,Tatiane R.ABSTRACT Motor and non-motor manifestations are common and disabling features of hereditary spastic paraplegia (HSP). Botulinum toxin type A (Btx-A) is considered effective for spasticity and may improve gait in these patients. Little is known about the effects of Btx-A on non-motor symptoms in HSP patients. Objective To assess the efficacy of Btx-A on motor and non-motor manifestations in HSP patients. Methods...
Derek Denny-Brown: the man behind the ganglia
Martinez,Alberto R. M.; Faber,Ingrid; Martins Jr,Carlos Roberto; Casseb,Raphael F.; Nucci,Anamarli; França Jr,Marcondes C.; Teive,Hélio A. G.ABSTRACT The authors present an historical review about the main contributions of Professor Derek Denny-Brown to neurology. Some of his achievements include the first description of sensory neuronopathies, and some of the essential textbooks on the function and anatomy of the basal ganglia. In 2016, on the 35th anniversary of his death, modern neurologists are still strongly influenced by his legacy.
Hereditary spastic paraplegia from 1880 to 2017: an historical review
Faber,Ingrid; Pereira,Eduardo Rafael; Martinez,Alberto R. M.; França Jr,Marcondes; Teive,Hélio Afonso GhizoniABSTRACT The authors have constructed a brief timeline of major clinical research related to hereditary spastic paraplegia (HSP). This timeline summarizes the evolution of HSP research, from the first clinical descriptions by Adolf von Strümpell in 1880 to the present day, with the transformation of these diseases into a rapidly-growing and heterogeneous group of neurogenetic diseases.
Translation and validation into Brazilian Portuguese of the Spastic Paraplegia ...
Servelhere,Katiane R.; Faber,Ingrid; Coan,Ana Carolina; França Junior,MarcondesABSTRACT Hereditary spastic paraplegias (HSP) are characterized by progressive lower limb weakness and spasticity. There are no validated instruments to quantify disease severity in Portuguese. Objective To translate and validate the Spastic Paraplegia Rating Scale (SPRS) into Brazilian-Portuguese. Method Two experienced and English-fluent neurologists translated SPRS into Portuguese, creating SPRS-BR. We then ...
Cognitive dysfunction in hereditary spastic paraplegias and other motor neuron ...
Faber,Ingrid; Branco,Lucas Melo T.; França Júnior,Marcondes CavalvanteABSTRACT Hereditary spastic paraplegia (HSP) is a diverse group of single-gene disorders that share the predominant clinical feature of progressive lower limb spasticity and weakness. More than 70 different genetic subtypes have been described and all modes of inheritance are possible. Intellectual dysfunction in HSP is frequent in recessive forms but rare in dominant families. It may manifest by either mental ...
Clinical features and management of hereditary spastic paraplegia
Faber,Ingrid; Servelhere,Katiane R.; Martinez,Alberto R. M.; D?Abreu,Anelyssa; Lopes-Cendes,Iscia; França Jr,Marcondes C.Hereditary spastic paraplegia (HSP) is a group of genetically-determined disorders characterized by progressive spasticity and weakness of lower limbs. An apparently sporadic case of adult-onset spastic paraplegia is a frequent clinical problem and a significant proportion of cases are likely to be of genetic origin. HSP is clinically divided into pure and complicated forms. The later present with a wide range ...