3 documents found, page 1 of 1
Roman coins at the edge of the Negev: characterisation of copper alloy artefact...
Peters, M; Goren, Y; Fabian, P; Bottaini, C; Grassini, S; Angelini, E; Mirao, jThe research presented in this paper focused on the preliminary non- and semi-destructive analysis of copper alloys, corrosion, and soil components from a Roman archaeological site in Israel. Investigations using portable X-ray fluorescence, X-ray diffraction and scanning electron microscopy with energy dispersive spectroscopy as well as micromorphological analyses were carried out to gain a better understandin...
A selective p53 activator and anticancer agent to improve colorectal cancer the...
Ramos, H; Soares, MIL; Silva, J; Raimundo, L; Calheiros, J; Gomes, C; Reis, F; Monteiro, FA; Nunes, C; Reis, S; Bosco, B; Piazza, S; Domingues, LImpairment of the p53 pathway is a critical event in cancer. Therefore, reestablishing p53 activity has become one of the most appealing anticancer therapeutic strategies. Here, we disclose the p53-activating anticancer drug (3S)-6,7-bis(hydroxymethyl)-5-methyl-3-phenyl-1H,3H-pyrrolo[1,2-c]thiazole (MANIO). MANIO demonstrates a notable selectivity to the p53 pathway, activating wild-type (WT)p53 and restoring W...
Chemically monoubiquitinated PEX5 binds to the components of the peroxisomal do...
Hagmann, V; Sommer, S; Fabian, P; Bierlmeier, J; van Treel, N; Mootz, H; Schwarzer, D; Azevedo, JE; Dodt, GPeroxisomal matrix proteins contain either a peroxisomal targeting sequence 1 (PTS1) or a PTS2 that are recognized by the import receptors PEX5 and PEX7, respectively. PEX5 transports the PTS1 proteins and the PEX7/PTS2 complex to the docking translocation module (DTM) at the peroxisomal membrane. After cargo release PEX5 is monoubiquitinated and extracted from the peroxisomal membrane by the receptor export ma...