2 documents found, page 1 of 1
Serum Adipokines as Predictors for the Outcome of Prostate Biopsies at Early St...
Ahmad, Ardalan E.; Mohammed, Aza; Bhindi, Bimal; Richard, Patrick O.; Fadaak, Kamel; Leão, Ricardo; Finelli, Antonio; Fleshner, Neil E.Purpose: Elevated adipokines in patients with obesity and metabolic syndrome have been linked to increased risk of prostate cancer (PCa). The association between select serum adipokines and the outcome of prostate biopsies alone and in combination with clinical parameters at different early stages of PCa was investigated. Patients and methods: Clinical data and serum adipokines were retrieved from three retrosp...
Combined genetic and epigenetic alterations of the TERT promoter affect clinica...
Leão, Ricardo; Lee, Donghyun; Figueiredo, Arnaldo; Hermanns, Thomas; Wild, Peter; Komosa, Martin; Lau, Irene; Mistry, Mathew; Nunes, Nuno MiguelIn urothelial bladder cancer (UBC), risk stratification remains an important unmet need. Limitless self-renewal, governed by TERT expression and telomerase activation, is crucial for cancer progression. Thus, telomerase activation through the interplay of mutations (TERTpMut ) and epigenetic alterations in the TERT promoter may provide further insight into UBC behavior. Here, we investigated the combined effect...