2 documents found, page 1 of 1
Brain–blood barrier breakdown and pro-inflammatory mediators in neonate rats su...
Barichello, Tatiana; Fagundes, Glauco D.; Generoso, Jaqueline S.; Moreira, Ana Paula; Costa, Caroline S.; Zanatta, Jessiele R.; Simões, Lutiana R.Neonatal meningitis is an illness characterized by inflammation of the meninges and occurring within the birth and the first 28 days of life. Invasive infection by Streptococcus pneumoniae, meningitis and sepsis, in neonate is associated with prolonged rupture of membranes; maternal colonization/illness, prematurity, high mortality and 50% of cases have some form of disability. For this purpose, we measured bra...
Environmental enrichment restores cognitive deficits induced by experimental ch...
Barichello, Tatiana; Fagundes, Glauco D.; Generoso, Jaqueline S.; Dagostin, Caroline S.; Simões, Lutiana R.; Vilela, Márcia C.; Comim, Clarissa M.To evaluate the influence of environmental enrichment (EE) on memory, cytokines, and brain-derived neurotrophic factor (BDNF) in the brain of adult rats subjected to experimental pneumococcal meningitis during infancy. On postnatal day 11, the animals received either artificial cerebrospinal fluid (CSF) or Streptococcus pneumoniae suspension intracisternally at 1 × 106 CFU/mL and remained with their mothers unt...