5 documents found, page 1 of 1
Combining the amplification refractory mutation system and high-resolution melt...
Oliveira, Beatriz B.; Costa, Beatriz; Morão, Barbara; Faias, Sandra; Veigas, Bruno; Pereira, Lucília Pebre; Albuquerque, Cristina; Maio, RuiThe success of personalized medicine depends on the discovery of biomarkers that allow oncologists to identify patients that will benefit from a particular targeted drug. Molecular tests are mostly performed using tumor samples, which may not be representative of the tumor's temporal and spatial heterogeneity. Liquid biopsies, and particularly the analysis of circulating tumor DNA, are emerging as an interestin...
Endoscopic ultrasound with fine needle aspiration is useful in pancreatic cysts...
Faias, Sandra; Cravo, Marília; Pereira da Silva, João; Chaves, Paula; Dias Pereira, A.Background: In current guidelines, endoscopic ultrasound with fne-needle aspiration (EUS-FNA) is recommended in pancreatic cystic lesions (PCLs) with worrisome features (size≥3 cm, mural nodule, or Wirsung dilation). Objective: To evaluate the diagnostic ability and assess the accuracy of EUS-FNA in PCLs smaller than 3 cm. Methods: Retrospective study of PCLs<3 cm (2007–2016) undergoing EUS-FNA. Clinical, EUS a...
A second endoscopic ultrasound with fine‐needle aspiration for cytology identif...
Faias, Sandra; Pereira, Luisa; Fonseca, Ricardo; Chaves, Paula; Dias Pereira, António; Cravo, MaríliaBackground: Endoscopic ultrasound with fine-needle aspiration (EUS-FNA) is recommended for diagnosis of pancreatic cystic lesions (PCLs). Its role in surveillance is unclear. Our goal was to determine if a second EUS-FNA changes diagnosis or management of PCLs. Methods: A retrospective analysis of an EUS database, searching for EUS-FNAs in PCLs from 2007 to 2017 was performed. Demographics, cyst characteristics...
KRAS in Cyst Fluid Obtained by Endoscopic Ultrasound-Fine-Needle Aspiration in ...
Faias, Sandra; Pereira, L.; Luís, Ângelo; Cravo, Marília; Dias Pereira, António; Torres, JoanaTo evaluate the diagnostic accuracy of KRAS mutation in pancreatic cystic fluid and compare it with carcinoembryonic antigen and cytology, we identified studies with cyst fluid obtained by endoscopic ultrasound prior to surgery. We classified cysts as malignant, premalignant, and benign. A random-effects model was used for quantitative meta-analysis. Pooled sensitivities, specificities, and summary receiver ope...
Genetic testing vs microforceps biopsy in pancreatic cysts: Systematic review a...
Faias, Sandra; Pereira, L.; Luís, Ângelo; Chaves, Paula; Cravo, MaríliaBackground: Carcinoembryonic antigen (CEA) and cytology in pancreatic cystic fluid are suboptimal for evaluation of pancreatic cystic neoplasms. Genetic testing and microforceps biopsy are promising tools for pre-operative diagnostic improvement but comparative performance of both methods is unknown. Aim: To compare the accuracy of genetic testing and microforceps biopsy in pancreatic cysts referred for surgery...