Introduction: Septal perforations remain a surgical challenge, prompting the development of new approaches and techniques to optimize closure rates. When symptomatic, perforations can cause nasal obstruction or recurrent epistaxis, requiring treatment. This study reports two clinical cases of symptomatic septal perforations. Objective: To describe the diagnosis, treatment, and surgical outcomes, accompanied by ...
Objective: To study the prevalence of hearing loss in children with congenital Cytomegalovirus infection and the influence of the type of maternal infection, symptoms and neonatal treatment with valganciclovir. Study design: Retrospective cohort Material and Methods: Data was collected through computerized processes of children with congenital Citomegalovirus, followed in Hospital de Guimarães, between 2017 and...
The synaptonemal complex (SC) is a proteinaceous scaffold that is assembled between paired homologous chromosomes during the onset of meiosis. Timely expression of SC coding genes is essential for SC assembly and successful meiosis. However, SC components have an intrinsic tendency to self-organize into abnormal repetitive structures, which are not assembled between the paired homologs and whose formation is po...
Background: physical restraint in psychiatric services is a common practice, which can compromise a person’s freedom, self-determination, dignity and life. Associated with efforts to minimize the use of this measure, the nurse-patient ratio factor has been little studied. Objective: to analyze the influence of the nurse-patient ratio in psychiatric services on the use of physical restraint and isolation. Method...
O relatório apresenta o resultado de um trabalho desenvolvido na empresa Herculano do Grupo FERPINTA, tendo como objetivo a aplicação dos conceitos e ferramentas da gestão de operações. O trabalho apresenta as soluções estudadas e preparadas para a implementação de um comboio logístico na secção de corte e conformação, com o foco a maquinação do balde para os tratores John Deere. O método utilizado, com recurso...
Duplication of the digestive tract is a rare condition, usually diagnosed at a young age. Late diagnosis can be associated with complications such as bowel obstruction, hemorrhage, or perforation.We present the case of a 60-year-old patient admitted to the emergency department due to abdominal pain and constipation.In the computed tomography scan, she presented a large fecaloma of the sigmoid colon causing larg...
The development of protocols for mobile networks, especially for vehicular ad-hoc networks (VANETs), presents great challenges in terms of testing in real conditions. Using a production network for testing communication protocols may not be feasible, and the use of small networks does not meet the requirements for mobility and scale found in real networks. The alternative is to use simulators and emulators, but...
The NineTeen Complex (NTC), also known as pre-mRNA-processing factor 19 (Prp19) complex, regulates distinct spliceosome conformational changes necessary for splicing. During Drosophila midblastula transition, splicing is particularly sensitive to mutations in NTC-subunit Fandango, which suggests differential requirements of NTC during development. We show that NTC-subunit Salsa, the Drosophila ortholog of human...
The NineTeen Complex (NTC), also known as pre-mRNA-processing factor 19 (Prp19) complex, regulates distinct spliceosome conformational changes necessary for splicing. During Drosophila midblastula transition, splicing is particularly sensitive to mutations in NTC-subunit Fandango, which suggests differential requirements of NTC during development. We show that NTC-subunit Salsa, the Drosophila ortholog of human...
Human oocytes can stay dormant for several decades in meiotic arrest, before reactivation and maturation. Similar, Drosophila oocyte is mostly transcriptionally quiescent during prophase I-arrest, transiently reactivating gene expression just before it progresses into metaphase I. Our aim is to better understand such reactivation and its role for oocyte maturation and female fertility. This work is divided in 3...