6 documents found, page 1 of 1
Spatial and Temporal Variations in Secondary Metabolites Content of the Brazili...
Gobbo-Neto,Leonardo; Bauermeister,Anelize; Sakamoto,Humberto T.; Gouvea,Dayana R.; Lopes,João Luis C.; Lopes,Norberto P.The genus Lychnophora (Asteraceae) is a medicinal plant traditionally used as anti-inflammatory or analgesic agent. Its biological properties have been widely investigated and correlated with its chemical composition, which could be different between the species and even accordingly to the place and season of collection. In this work, it was investigated the spatial and temporal variations in the secondary meta...
Seasonal variation of the major secondary metabolites present in the extract of...
Gouvea,Dayana Rubio; Gobbo-Neto,Leonardo; Sakamoto,Humberto T.; Lopes,Norberto Peporine; Lopes,João Luís Callegari; Meloni,FernandoThe species Eremanthus mattogrossensis, known as "veludo do cerrado" (cerrado velvet), is native to the Brazilian Cerrado. Because the amount of metabolites present in plants may be influenced by biological and environmental factors, here we conducted an HPLC-DAD-MS/MS investigation of the metabolite concentrations found in the MeOH/H2O extract of the leaves of this species. The main compounds were identified a...
In vitro study of antioxidant and scavenger properties of phenolic compounds fr...
Grael,Cristiane F. F.; Kanashiro,Alexandre; Kabeya,Luciana M.; Jordão,Christiane O.; Takeara,Renata; Gobbo-Neto,Leonardo; Polizello,Ana Cristina M.This paper describes the antioxidant effects of thirteen phenolic compounds isolated from plants of the genus Lychnophora. Two assays were performed to evaluate these effects: a cellular test that measured the luminol-enhanced chemiluminescence produced by neutrophils stimulated with opsonized zymosan and a cell-free test involving horseradish peroxidase-H2O2-luminol. In both assays, the antioxidant activity of...
Differential metabolic and biological profiles of Lychnophora ericoides mart. (...
Gobbo-Neto,Leonardo; Guaratini,Thais; Pessoa,Cláudia; Moraes,Manoel O. de; Costa-Lotufo,Letícia V.; Vieira,Roberto F.; Colepicolo,Pio; Lopes,Norberto P.This paper reports HPLC-DAD-MS/MS and HPLC-ECD characterisation of secondary metabolite profiles of Lychnophora ericoides Mart. leaf extracts from different provenances and their cytotoxic and antioxidant properties. Leaf extracts from populations representing seven different locations were evaluated for antioxidant activity by the DPPH radical scavenging system and activity towards cellular growth in three tum...
Plantas medicinais: fatores de influência no conteúdo de metabólitos secundários
Gobbo-Neto,Leonardo; Lopes,Norberto P.Since secondary metabolites represent a chemical interface between plants and surrounding environment, their syntheses are frequently affected by environmental conditions. Thus, variations in the total content and/or of the relative proportions of secondary metabolites in plants can take place. We review the main environmental factors that can streamline or alter the production or concentration of secondary met...
Quantitative HPLC analysis of sesquiterpene lactones and determination of chemo...
Sakamoto,Humberto T.; Gobbo-Neto,Leonardo; Cavalheiro,Alberto J.; Lopes,Norberto P.; Lopes,João L. C.Eremanthus seidelii MacLeish & Schumacher has a restricted occurrence to the Brazilian "cerrado" surrounding the Furnas (MG) reservoir, in environments that have been seriously damaged by human activity. The present phytochemical investigation reveals that the sesquiterpene lactones (SL) 4beta,5-dihydro-2',3'-dihydroxy-15-desoxy-goyazensolide (1) and 4beta,5-dihydro-1',2'-epoxy-eremantholide-C (2) are the m...