Encontrados 79 documentos, a visualizar página 1 de 8
Therapeutic Drug Monitoring of Amikacin in Neutropenic Oncology Patients
Aquino, Maria; Tinoco, Maria; Bicker, Joana; Falcão, Amílcar; Rocha, Marília João; Fortuna, AnaAmikacin is the antibiotic of choice for the treatment of Gram-negative infections, namely, those in neutropenic oncology patients. No populational pharmacokinetic studies are currently available reporting amikacin pharmacokinetics in neutropenic oncology patients despite their specific pathophysiological features and treatments. A large-scale retrospective study was herein conducted to specifically investigate...
Population Pharmacokinetic Analysis of Perampanel in Portuguese Patients Diagno...
Silva, Rui; Colom, Helena; Bicker, Joana; Almeida, Anabela; Silva, Ana; Sales, Francisco; Santana, Isabel; Falcão, Amílcar; Fortuna, AnaPerampanel is a promising antiepileptic drug (AED) for refractory epilepsy treatment due to its innovative mechanism of action. This study aimed to develop a population pharmacokinetic (PopPK) model to be further used in initial dose optimization of perampanel in patients diagnosed with refractory epilepsy. A total of seventy-two plasma concentrations of perampanel obtained from forty-four patients were analyze...
Antibody and Nanobody Radiolabeling with Copper-64: Solid vs. Liquid Target App...
Hrynchak, Ivanna; Cocioabă, Diana; Fonseca, Alexandra I.; Leonte, Radu; Carmo, Sérgio do; Cornoiu, Roxana; Falcão, Amílcar; Niculae, DanaAntibody and nanobody-based copper-64 radiopharmaceuticals are increasingly being proposed as theranostic tools in multiple human diseases. While the production of copper-64 using solid targets has been established for many years, its use is limited due to the complexity of solid target systems, which are available in only a few cyclotrons worldwide. In contrast, liquid targets, available in virtually in all cy...
Intranasal Microemulsion as an Innovative and Promising Alternative to the Oral...
Meirinho, Sara; Rodrigues, Márcio; Santos, Adriana O; Falcão, Amílcar; Alves, GilbertoStiripentol (STP) is a new-generation antiepileptic only available for oral administration. However, it is extremely unstable in acidic environments and undergoes gastrointestinal slow and incomplete dissolution. Thus, STP intranasal (IN) administration might overcome the high oral doses required to achieve therapeutic concentrations. An IN microemulsion and two variations were herein developed: the first conta...
Exploring the Antioxidant, Antidiabetic, and Antimicrobial Capacity of Phenolic...
Gonçalves, Ana C.; Nunes, Ana R.; Meirinho, Sara; Ayuso-Calles, Miguel; Roca-Couso, Rocío; Rivas, Raúl; Falcão, Amílcar; Alves, Gilberto; Silva, Luís R.(1) Background: Nowadays, special attention has been paid to red and purple fruits, including blueberries and sweet cherries, since they are highly attractive to consumers due to their organoleptic properties, standing out due to their vibrant red and purple colours and sweet flavour, and nutritional value. (2) Methods: The present study evaluated the phenolic profile of phenolic-enriched extracts from blueberr...
Intranasal delivery of lipid-based nanosystems as a promising approach for brai...
Meirinho, Sara; Rodrigues, Márcio; Ferreira, Catarina; Caetano Oliveira, Rui; Fortuna, Ana; Santos, Adriana; Falcão, Amílcar; Alves, GilbertoPerampanel (PER), a new-generation antiepileptic drug effective against different types of seizures, has already demonstrated a potential in status epilepticus therapy. Considering the growing interest of intranasal (IN) administration for nose-to-brain delivery, PER could be envisioned as a good candidate for this route, especially if formulated in a lipid-based nanosystem. With that purpose, a hydrophobic for...
Study of the metabolic stability profiles of perampanel, rufinamide and stiripe...
Meirinho, Sara; Rodrigues, Márcio; Fortuna, Ana; Falcão, Amílcar; Alves, GilbertoNew-generation antiepileptic drugs as perampanel, rufinamide and stiripentol emerged as alternatives in chronic epilepsy polytherapy. Hence, their metabolic stability and potential involvement in relevant drug-drug interactions (DDI) are of great clinical interest, being HepaRG cells herein used as an in vitro human model. To characterize their metabolic stability profiles, HepaRG cells were incubated with pera...
Self-Emulsifying Drug Delivery Systems: An Alternative Approach to Improve Brai...
Meirinho, Sara; Rodrigues, Márcio; Santos, Adriana; Falcão, Amílcar; Alves, GilbertoEfforts in discovering new and effective neurotherapeutics are made daily, although most fail to reach clinical trials. The main reason is their poor bioavailability, related to poor aqueous solubility, limited permeability through biological membranes, and the hepatic first-pass metabolism. Nevertheless, crossing the blood-brain barrier is the major drawback associated with brain drug delivery. To overcome it,...
Clinical pharmacists interventions in the management of type 2 diabetes mellitu...
Pousinho, Sarah; Morgado, Manuel; Plácido, Ana; Roque, Fátima; Falcão, Amílcar; Alves, GilbertoBackground: Type 2 diabetes mellitus is a chronic disease that is reaching epidemic proportions worldwide. It is imperative to adopt an integrated strategy, which involves a close collaboration between the patient and a multidisciplinary team of which pharmacists should be integral elements. Objective: This work aims to identify and summarize the main effects of interventions carried out by clinical pharmacists...
Effectiveness of an intervention to improve antibiotic-prescribing behaviour in...
Rodrigues, António; Roque, Fátima; Piñeiro-Lamas, Maria; Falcão, Amílcar; Figueiras, Adolfo; Herdeiro, MariaBackground: High rates of antibiotic misprescribing in primary care, with alarming clinical and economic consequences, highlight the urgent need for interventions to improve antibiotic prescribing in this setting. Objectives: To assess the effectiveness on antibiotic prescribing quality indicators of a multifaceted intervention targeting health professionals' and patients' behaviour regarding antibiotic use. Me...