9 documents found, page 1 of 1
Risperidone-ISM® effectiveness and tolerability in acute schizophrenia patients...
Correll, Christoph U.; Rohner, Henrik; Dimalta, Savino; Göldner, Randi Susanne; Assion, Hans Jörg; Langner-Timm, Steffi; Núñez Sande, CarmenObjective: To evaluate the effectiveness, time to discharge, functioning, and tolerability of Risperidone-ISM® in hospitalised patients with schizophrenia relapse. Methods: Non-interventional, multicentre, prospective study of adults admitted for acute exacerbation of schizophrenia and treated with Risperidone-ISM®. Effectiveness was assessed using the Clinical Global Impression-Severity scale (CGI-S) and 6-ite...
Clinician treatment choices for post-traumatic stress disorder (PTSD) - Ambassa...
Kuzman, Martina Rojnic; Padberg, Frank; Amann, Benedikt L.; Schouler-Ocak, Meryam; Bajic, Zarko; Melartin, Tarja; James, Adrian; Beezhold, JulianBackground: Considering the recently growing number of potentially traumatic events and stressors in Europe (i.e. war in Ukraine, COVID-19 pandemic, refugee waves), the European Psychiatric Association (EPA) undertook a study to investigate clinicians' treatment choices for Post-Traumatic Stress Disorder (PTSD). Results: The case-based analysis included 611 participants, who correctly classified the vignette as...
The safety of agomelatine in standard medical practice in depressed patients : ...
Gorwood, Philip; Benichou, Jacques; Moore, Nicholas; Álvarez Martínez, Enric; Mertens, Joost; Aguglia, Eugenio; Figueira, Maria Luísa; Falkai, PeterObjective: The present observational cohort study documented the safety of agomelatine in current medical practice in out-patients suffering from major depressive disorder. Method: The 6-month evolution of agomelatine-treated patients was assessed with a focus on safety (emergent adverse events, liver acceptability), severity of depression using the Clinical Global Impression Severity (CGI-S) score, and functio...
Transcriptome studies in the context of disturbed connectivity in schizophrenia
Schmitt, Andrea; Reich-Erkelenz, Daniela; Gebicke-Härter, Peter; Falkai, PeterEsquizofrenia é uma severa doença neurobiológica com fatores genéticos e ambientais desempenhando um papel na fisiopatologia. Diversas regiões cerebrais têm sido implicadas no processo da doença e estão conectadas em complexos circuitos neuronais. Nos níveis molecular e celular, a conectividade afetada entre essas regiões, envolvendo mielinização disfuncional dos axônios neuronais, bem como as alterações no nív...
The role of the cerebellum in schizophrenia: from cognition to molecular pathways
Yeganeh-Doost, Peyman; Gruber, Oliver; Falkai, Peter; Schmitt, AndreaBeside its role in motor coordination, the cerebellum is involved in cognitive function such as attention, working memory, verbal learning, and sensory discrimination. In schizophrenia, a disturbed prefronto-thalamo-cerebellar circuit has been proposed to play a role in the pathophysiology. In addition, a deficit in the glutamatergic N-methyl-D-aspartate (NMDAf) receptor has been hypothesized. The risk gene neu...
Parieto-prefrontal dysfunction during visuo-auditory information processing in ...
Schmitt, Andrea; Otto, Sylvia; Jatzko, Alexander; Ruf, Matthias; Demirakca, Traute; Tost, HeiKe; Gruber, Oliver; Parlapani, Eleni; Falkai, PeterOBJECTIVES: In first-episode schizophrenia patients, functional magnetic resonance imaging (fMRI) has shown prefronto-parietal dysfunction during acoustic and visual stimulation. The aim of this study was to investigate the prefronto-parietal network in elderly schizophrenia patients using the same paradigm. Additionally, we hypothesized favourable effects on brain activation by the atypical antipsychotic cloza...
Is brain banking of psychiatric cases valuable for neurobiological research?
Schmitt, Andrea; Parlapani, Eleni; Bauer, Manfred; Heinsen, Helmut; Falkai, PeterIt is widely accepted that neurobiological abnormalities underlie the symptoms of psychiatric disorders such as schizophrenia and unipolar or bipolar affective disorders. New molecular methods, computer-assisted quantification techniques and neurobiological investigation methods that can be applied to the human brain are all used in post-mortem investigations of psychiatric disorders. The following article desc...
World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for b...
Falkai, Peter; Wobrock, Thomas; Lieberman, Jeffrey; Glenthoj, Birte; Gattaz, Wagner F.; Möller, Hans-JürgenThese guidelines for the biological treatment of schizophrenia were developed by an international Task Force of the World Federation of Societies of Biological Psychiatry (WFSBP). The goal during the development of these guidelines was to review systematically all available evidence pertaining to the treatment of schizophrenia, and to reach a consensus on a series of practice recommendations that are clinically...
World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for b...
Falkai, Peter; Wobrock, Thomas; Lieberman, Jeffrey; Glenthoj, Birte; Gattaz, Wagner F.; Möller, Hans-JürgenThese guidelines for the biological treatment of schizophrenia were developed by an international Task Force of the World Federation of Societies of Biological Psychiatry (WFSBP). The goal during the development of these guidelines was to review systematically all available evidence pertaining to the treatment of schizophrenia, and to reach a consensus on a series of practice recommendations that are clinically...