2 documents found, page 1 of 1
Dectin-1 Y238X polymorphism associates with susceptibility to invasive aspergil...
Cunha, Cristina; Ianni, Mauro Di; Bozza, Silvia; Giovannini, Gloria; Zagarella, Silvia; Zelante, Teresa; Angelo, Carmen de; Pierini, AntonioThe C-type lectin receptor Dectin-1 plays a pivotal role in antifungal immunity. In this study, the recently characterized human DECTIN1 Y238X early stop codon polymorphism leading to diminished Dectin-1 receptor activity was studied in relation to invasive aspergillosis susceptibility and severity in patients receiving hematopoietic stem cell transplantation. We found that the presence of the DECTIN1 Y238X pol...
Polymorphisms in Toll-like receptor genes and susceptibility to infections in a...
Carvalho, Agostinho; Cunha, Cristina; Carotti, Alessandra; Aloisi, Teresa; Guarrera, Ornella; Di Ianni, Mauro; Falzetti, Franca; Bistoni, FrancescoObjective Discovery of genetic variations in the genes encoding for Toll-like receptors (TLRs) has highlighted a potential link between genomic variation of the host and susceptibility to infections. Materials and Methods We investigated the association between polymorphisms in the TLR2, TLR4, and TLR9 genes in recipients of allogeneic hematopoietic stem cell transplant and susceptibility to infections caused b...