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Biodegradable polymeric nanocapsules prevent cardiotoxicity of anti-trypanosoma...

Branquinho, Renata Tupinambá; Roy, Jérôme; Farah, Charlotte; Garcia, Giani Martins; Aimond, Franck; Guennec, Jean Yves Le

Chagas disease is a neglected parasitic disease caused by the protozoan Trypanosoma cruzi. New antitrypanosomal options are desirable to prevent complications, including a high rate of cardiomyopathy. Recently, a natural substance, lychnopholide, has shown therapeutic potential, especially when encapsulated in biodegradable polymeric nanocapsules. However, little is known regarding possible adverse effects of l...

Date: 2017   |   Origin: Oasisbr
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