2 documents found, page 1 of 1
Rapid progression of CD8 and CD4 T cells to cellular exhaustion and senescence ...
Pedroso, Rodrigo B.; Torres, Lícia; Ventura, Lucas Araújo; Camatta, Giovanna Caliman; Mota, Catarina; Mendes, Ana Catarina; Ribeiro, FilipaRisk factors for the development of severe COVID-19 include several comorbidities, but age was the most striking one since elderly people were disproportionately affected by SARS-CoV-2 infection. Among the reasons for this markedly unfavorable response in the elderly, immunosenescence and inflammaging appear as major drivers of this outcome. A finding that was also notable was that hospitalized patients with se...
Regulatory T Cells Accumulate in the Lung Allergic Inflammation and Efficiently...
Faustino, Lucas; Mucida, Daniel; Keller, Alexandre Castro; Demengeot, Jocelyne; Bortoluci, Karina; Sardinha, Luiz Roberto; Carla Takenaka, MaisaFoxp3(+)CD25(+)CD4(+) regulatory T cells are vital for peripheral tolerance and control of tissue inflammation. In this study, we characterized the phenotype and monitored the migration and activity of regulatory T cells present in the airways of allergic or tolerant mice after allergen challenge. To induce lung allergic inflammation, mice were sensitized twice with ovalbumin/aluminum hydroxide gel and challeng...