4 documents found, page 1 of 1
Obesity impairs resistance to Leishmania major infection in C57BL/6 mice.
Martins, Vinicius Dantas; Campos, Franciele Carolina Silva; Moreira, Felipe Caixeta; Carneiro, Matheus Batista Heitor; Goes, Grazielle RibeiroAn association between increased susceptibility to infectious diseases and obesity has been described as a result of impaired immunity in obese individuals. It is not clear whether a similar linkage can be drawn between obesity and parasitic diseases. To evaluate the effect of obesity in the immune response to cutaneous Leishmania major infection, we studied the ability of C57BL/6 mice fed a hypercaloric diet (...
Ageing down-modulates liver inflammatory immune responses to schistosome infect...
Faria, Elaine Speziali de; Aranha, Claudio Henrique Magalhães; Carvalho, Andréa Teixeira de; Santiago, Andrezza Fernanda; Oliveira, Rafael Pires deAgeing is associated with several alterations in the immune system. Our aim in this study was to compare the development of immunity to Schistosoma mansoni infection in young versus aged C57Bl ⁄ 6 mice using the liver as the main organ to evaluate pathological alterations and immune responses. In the acute phase, young mice had large liver granulomas with fibrosis and inflammatory cells. Chronic phase in young ...
Immunoglobulin production is impaired in protein-deprived mice and can be resto...
Amaral, Joana Ferreira do; Foschetti, Daniela Abreu; Assis, Frankcinéia Aparecida de; Vaz, Nelson Monteiro; Silva, Juscilene Menezes daMost contacts with food protein and microbiota antigens occur at the level of the gut mucosa. In animal models where this natural stimulation is absent, such as germ-free and antigen-free mice, the gutassociated lymphoid tissue (GALT) and systemic immunological activities are underdeveloped. We have shown that food proteins play a critical role in the full development of the immune system. C57BL/ 6 mice weaned ...
Splenectomy does not interfere with immune response to Leishmania major infecti...
Maioli, Tatiani Uceli; Carneiro, Cláudia Martins; Assis, Frankcinéia Aparecida de; Faria, Ana Maria Caetano deSpleen is one of the largest lymphoid organs in the body; it harbors immune cells including antigen presenting cells, B and T lymphocytes. It has an important role in humoral and cellular immune responses. Herein we investigated the role of spleen in the immune response to experimental Leishmania major infection. It is known that C57BL/6 mice are resistant to L. major infection whereas BALB/c mice are susceptib...