13 documents found, page 1 of 2

Development of a healthy lifestyle assessment index for school-age children

Introduction: Assessing children's lifestyles is fundamental for developing policies that prevent the onset of non-communicable diseases. Objectives: To develop a short lifestyle index for school-age children (6 to 9 years old) and assess their lifestyle characterization. Methodology: The index was developed based on data from the 7-year follow-up of the birth cohort Generation XXI (n=4336 children), grouped in...

The contribution of complement to the pathogenesis of IgA nephropathy: Are comp...

Primary IgA nephropathy (IgAN) is a leading cause of chronic kidney disease and kidney failure for which there is no disease-specific treatment. However, this could change, since novel therapeutic approaches are currently being assessed in clinical trials, including complement-targeting therapies. An improved understanding of the role of the lectin and the alternative pathway of complement in the pathophysiolog...

Administration of intravenous iron formulations induces complement activation i...

Background: Intravenous (IV) iron is widely used to treat anemia in chronic kidney disease patients. Previously, iron formulations were shown to induce immune activation in-vitro. The current study aimed to investigate the effect of IV iron on complement activation in-vivo, and whether this subsequently induces inflammation and/or oxidative stress. Methods: Two distinct patient groups were included: 51 non-dial...

Intradialytic Complement Activation Precedes the Development of Cardiovascular ...

Background: Hemodialysis (HD) is a life-saving treatment for patients with end stage renal disease. However, HD patients have markedly increased rates of cardiovascular morbidity and mortality. Previously, a link between the complement system and cardiovascular events (CV-events) has been reported. In HD, systemic complement activation occurs due to blood-to-membrane interaction. We hypothesize that HD-induced ...

Intradialytic complement activation precedes the development of cardiovascular ...

Background: Hemodialysis (HD) is a life-saving treatment for patients with end stage renal disease. However, HD patients have markedly increased rates of cardiovascular morbidity and mortality. Previously, a link between the complement system and cardiovascular events (CV-events) has been reported. In HD, systemic complement activation occurs due to blood-to-membrane interaction. We hypothesize that HD-induced ...

Portuguese Consensus Document Statement in Diagnostic and Management of Atypica...

Among thrombotic microangiopathies (TMA), the hemolytic uremic syndrome associated with dysregulation of the alternative complement pathway (aHUS) is one of the most challenging diseases a nephrologist can face. By the end of the XXth century, the complement’s role was unraveled with the discovery that mutations in the factor H coding gene were responsible for aHUS. But it was the acknowledgment that pharmacolo...

Collagen Type IV-Related Nephropathies in Portugal: Pathogenic COL4A5 Mutations...

Alport syndrome (AS) is caused by pathogenic mutations in the genes encoding α3, α4 or α5 chains of collagen IV (COL4A3/COL4A4/COL4A5), resulting in hematuria, chronic renal failure (CRF), sensorineural hearing loss (SNHL) and ocular abnormalities. Mutations in the X-linked COL4A5 gene have been identified in 85% of the families (XLAS). In this study, 22 of 60 probands (37%) of unrelated Portuguese families, wi...

Desenvolvimento de uma base de dados sobre estabilidade de medicamentos/produto...

Análise das alterações do esquemas de tratamento antiretrovírico

3. Perfil de utilização de imunoglobulinas não específicas no Hospital de Braga