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Hypersensitivity Reactions to Vaccines: Current Evidence and Standards for SARS...

Carvalho, Jóni Costa; Cunha, Francisca; Coutinho, Iolanda Alen; Loureiro, Carlos; Faria, Emília; Bom, Ana Todo

The first reports of hypersensitivity reactions following the rollout of COVID-19 vaccination programs have raised public concern. Given the recent availability and novel mechanisms of COVID-19 vaccines, there is limited data on possible hypersensitivity reactions. Although it seems rare, the incidence of anaphylaxis for approved COVID-19 vaccines has been suggested as being higher when compared to previous vac...

Date: 2021   |   Origin: Acta Médica Portuguesa

The dysfunctional immune system in common variable immunodeficiency increases t...

Gullo, Irene; Costa, Catarina; Silva, Susana L.; Ferreira, Cristina; Motta, Adriana; Silva, Sara P.; Duarte Ferreira, Ruben; Rosmaninho, Pedro

Gastric carcinoma (GC) represents the most common cause of death in patients with common variable immunodeficiency (CVID). However, a limited number of cases have been characterised so far. In this study, we analysed the clinical features, bacterial/viral infections, detailed morphology and immune microenvironment of nine CVID patients with GC. The study of the immune microenvironment included automated digital...


Letter to the Editor: Primary Immunodeficiencies in Adults – Multicentric Coope...

Duarte Ferreira, Ruben; Silva, Sara; Carrapatoso, Isabel; Regateiro, Frederico; Santos, Natacha; Silva, Diana; Sousa, Filipa; Oliveira, Susana

N/A.; N/A.

Date: 2018   |   Origin: Acta Médica Portuguesa

The portuguese severe asthma registry : development, features, and data sharing...

Sousa, Ana Sá; Fonseca, João Almeida; Pereira, Ana Margarida; Ferreira, Ana; Arrobas, Ana; Mendes, Ana; Drummond, Marta; Videira, Wanda; Costa, Tiago

The Portuguese Severe Asthma Registry (Registo de Asma Grave Portugal, RAG) was developed by an open collaborative network of asthma specialists. RAG collects data from adults and pediatric severe asthma patients that despite treatment optimization and adequate management of comorbidities require step 4/5 treatment according to GINA recommendations. In this paper, we describe the development and implementation ...


Serratia osteomyelitis and chronic granulomatous disease.

Campos, Manuela; Rocha, Graça; Cordeiro, Ana; Lemos, Sónia; Paiva, Artur; Silva, Isabel; Faria, Emília

Chronic Granulomatous Disease (CGD) is a primary immunodeficiency disorder characterized by recurrent purulent infections of the skin, lungs, and reticuloendothelial organs, primarily due to staphylococci, enteric bacteria, fungi, and occasionally mycobacteria. More than two thirds of all cases are X-linked and result from defects in the CYBB gene that encodes the gp91-phox subunit of NADPH oxidase. The authors...

Date: 2011   |   Origin: Acta Médica Portuguesa

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