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Helicobacter spp. in the Stomach of Cats: Successful Colonization and Absence o...

Teixeira, S; Filipe, D; Cerqueira, M; Barradas, P; Nunes, FC; Faria, F; Haesebrouck, F; Mesquita, JR; Gärtner, F; Amorim, I

In addition to Helicobacter pylori, many non-Helicobacter pylori Helicobacters (NHPH) are able to cause gastric disease in humans. Cats are a natural reservoir for many of these species. Accordingly, living in close and intimate contact with animals has been identified as a risk factor, and an important zoonotic significance has therefore been attributed to NHPH. To determine the prevalence and associated gastr...


Nipple Hibernoma in a Dog: A Case Report With Literature Review

Amorim, I; Faria, F; Taulescu, M; Taulescu, C; Gärtner, F

This report provides a clinical, histological, and immunohistochemical description of an unusual hibernoma (pale cell variant) in the subepidermal area of the nipple of a six-year-old bitch. Furthermore, an extensive literature review of hibernomas in animals was made. Physical examination revealed a nodular lesion in the subepidermal area of the third nipple of the left mammary chain. The histopathological fin...


In vitro and in vivo characterization of PLLA-316L stainless steel electromecha...

Branquinho, MV; Ferreira, SO; Alvites, RD; Magueta, AF; Ivanov, M; Sousa, AC; Amorim, I; Faria, F; Fernandes, MHV; Vilarinho, PM; Maurício, AC

Bone injuries represent a major social and financial impairment, commonly requiring surgical intervention due to a limited healing capacity of the tissue, particularly regarding critical-sized defects and non-union fractures. Regenerative medicine with the application of bone implants has been developing in the past decades towards the manufacturing of appropriate devices. This work intended to evaluate medical...


Rat Olfactory Mucosa Mesenchymal Stem/Stromal Cells (OM-MSCs): A Characterizati...

Alvites, RD; Branquinho, MV; Caseiro, AR; Amorim, I; Santos Pedrosa, S; Rêma, A; Faria, F; Porto, B; Oliveira, C; Teixeira, P; Magalhães, R; Geuna, S

Stem/stromal cell-based therapies are a branch of regenerative medicine and stand as an attractive option to promote the repair of damaged or dysfunctional tissues and organs. Olfactory mucosa mesenchymal stem/stromal cells have been regarded as a promising tool in regenerative therapies because of their several favorable properties such as multipotency, high proliferation rate, helpful location, and few associ...


Mesenchymal Stem/ Stromal Cells metabolomic and bioactive factors profiles: A c...

Caseiro, AR; Pedrosa, SS; Ivanova, G; Branquinho, MV; Almeida, A; Faria, F; Amorim, I; Pereira, T; Maurício, AC

Mesenchymal Stem/ Stromal Cells assume a supporting role to the intrinsic mechanisms of tissue regeneration, a feature mostly assigned to the contents of their secretome. A comparative study on the metabolomic and bioactive molecules/factors content of the secretome of Mesenchymal Stem/ Stromal Cells derived from two expanding sources: the umbilical cord stroma and the dental pulp is presented and discussed. Th...


Local iron homeostasis in the breast ductal carcinoma microenvironment

Marques, O; Porto, G; Rêma, A; Faria, F; Cruz, PA; Gomez-Lazaro, M; Silva, P; Martins da Silva, B; Lopes, C

Background: While the deregulation of iron homeostasis in breast epithelial cells is acknowledged, iron-related alterations in stromal inflammatory cells from the tumor microenvironment have not been explored. Methods: Immunohistochemistry for hepcidin, ferroportin 1 (FPN1), transferrin receptor 1 (TFR1) and ferritin (FT) was performed in primary breast tissues and axillary lymph nodes in order to dissect the i...


A comparison of Helicobacter pylori and non-Helicobacter pylori Helicobacter sp...

Amorim, I; Freitas, DP; Magalhães, A; Faria, F; Lopes, C; Faustino, A; Smet, A; Haesebrouck, F; Reis, CA; Gärtner, F

Background: The gastric mucosa of dogs is often colonized by non-Helicobacter pylori helicobacters (NHPH), while H. pylori is the predominant gastric Helicobacter species in humans. The colonization of the human gastric mucosa by H. pylori is highly dependent on the recognition of host glycan receptors. Our goal was to define the canine gastric mucosa glycophenotype and to evaluate the capacity of different gas...


Lesão Medular Iatrogénica - Realidade no Centro do Alcoitão

Camões Barbosa, A; Paradinha, S; Condeça, B; Faria, F

Objectivos: A etiologia da lesão medular (LM) é diversa, incluindo, para além da iatrogenia, causas traumáticas,vasculares, neoplásicas, infecciosas, degenerativas, metabólicas e congénitas. Não se conhece a verdadeiracontribuição relativa de cada grupo etiológico na incidência desta patologia no mundo. Numa investigação daliteratura existente foi encontrado apenas um estudo retrospectivo (Bacher et al.) que es...


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