38 documents found, page 1 of 4
Evaluation of radiotherapy doses in pediatric patients with Hodgkin Lymphoma: M...
Mota, Inês; Cravo Sá, Ana; Costa, Fernando; Monteiro, Armanda; Aires, Fátima; Faria, IsabelBackground: Hodgkin lymphoma (HL) is one of the most common cancers in children, and radiotherapy (RT) is a crucial part of treatment [1,2]. However, the risk of late effects, such as cardiotoxicity and secondary malignant neoplasms, is a concern due to radiation exposure to critical organs [2-8]. Advanced dose calculation methods, such as Monte Carlo Methods (MCMs), can improve dosimetry accuracy and help mini...
Radiotherapy metastatic prostate cancer cell lines treated with gold nanorods m...
Soares, Sílvia; Aires, Fátima; Monteiro, Armanda; Pinto, Gabriela; Faria, Isabel; Sales, Goreti; Correa-Duarte, Miguel A.; Guerreiro, SusanaMicroRNA (miRNA) modulation has been identified as a promising strategy for improving the response of human prostate cancer (PCa) to radiotherapy (RT). Studies have shown that mimics or inhibitors of miRNAs could modulate the sensitivity of PCa cells to RT. In addition, pegylated gold nanoparticles have been studied as a therapeutic approach to treat PCa cells and/or vehicles for carrying miRNAs to the inside o...
Application of Gold Nanoparticles as Radiosensitizer for Metastatic Prostate Ca...
Soares, Sílvia; Faria, Isabel; Aires, Fátima; Monteiro, Armanda; Pinto, Gabriela; Sales, M. Goreti F.; Correa-Duarte, Miguel A.; Guerreiro, Susana G.More than 50% of all prostate cancer (PCa) patients are treated by radiotherapy (RT). Radioresistance and cancer recurrence are two consequences of the therapy and are related to dose heterogeneity and non-selectivity between normal and tumoral cells. Gold nanoparticles (AuNPs) could be used as potential radiosensitizers to overcome these therapeutic limitations of RT. This study assessed the biological interac...
Application of gold nanoparticles as radiosensitizer for metastatic prostate ca...
Soares, Sílvia; Faria, Isabel; Aires, Fátima; Monteiro, Armanda; Pinto, Gabriela; Sales, Maria Goreti; Correa-Duarte, Miguel A.; Guerreiro, Susana G.More than 50% of all prostate cancer (PCa) patients are treated by radiotherapy (RT). Radioresistance and cancer recurrence are two consequences of the therapy and are related to dose heterogeneity and non-selectivity between normal and tumoral cells. Gold nanoparticles (AuNPs) could be used as potential radiosensitizers to overcome these therapeutic limitations of RT. This study assessed the biological interac...
Application of gold nanoparticles as radiosensitizer for metastatic prostate ca...
Soares, Sílvia; Faria, Isabel; Aires, Fátima; Monteiro, Armanda; Pinto, Gabriela; Sales, Maria Goreti; Correa-Duarte, Miguel A.; Guerreiro, Susana G.More than 50% of all prostate cancer (PCa) patients are treated by radiotherapy (RT). Radioresistance and cancer recurrence are two consequences of the therapy and are related to dose heterogeneity and non-selectivity between normal and tumoral cells. Gold nanoparticles (AuNPs) could be used as potential radiosensitizers to overcome these therapeutic limitations of RT. This study assessed the biological interac...
The multiplicities of an ethics committee in higher education
Tavares, Diana; Cruz, Agostinho; Cabral, Ana Paula; Machado, Alberto; Sousa, Helena; Curado, Henrique; Faria, Isabel; Amorim, ManuelaIn the academic context, the main activity of ethics committees is evidently to regulate and monitor any investigation carried out within the institution, if the object of study is a person or biological material. However, it is important to note that ethics committee activity does not end, and cannot end, in this sphere of action. These entities are fundamental in raising awareness of the academic community fo...
A proteção dos dados pessoais na investigação e inovação em saúde
Curado, Henrique; Amorim, Manuela; Cabral, Ana Paula; Cruz, Agostinho; Faria, Isabel; Gonçalves, Maria João; Lopes, Paula; Machado, AlbertoInvestigação e inovação em saúde pressupõe o tratamento de dados pessoais sensíveis, protegidos pelo regulamento europeu de proteção de dados e pela legislação nacional. O presente estudo procura demonstrar a compatibilidade entre a investigação e inovação em saúde e as garantias de confidencialidade e proteção dos dados pessoais, indicando os pressupostos para tal, alertando para a fragilidade acrescida nos es...
Biomolecules in the relationship of cancer and obesity
Almeida, Joana; Coelho, Pedro; Prudêncio, Cristina; Vieira, Mónica; Fernandes, Rúben; Fonseca, Magda; Soares, Raquel; Silva, Liliana; Faria, IsabelObesity has been associated with various major causes of death and morbidity including malignant neoplasms. This increased prevalence has been accompanied by a worldwide increase in cutaneous melanoma incidence rates during the last decades, as well as gliomas, the most common primary malignant brain tumors in adults (Almeida et al., 2019). Although obesity aetiology is established, the implicated mechanisms re...
The relevance of an ethics committee in a higher education institution in the h...
Monteiro, Pedro; Tavares, Diana; Cruz, Agostinho; Cabral, Ana Paula; Machado, Alberto; Curado, Henrique; Sousa, Helena; Faria, IsabelEthics Committees arose as consequence of medical-scientific advances made in an eminent demand to extend morality and ethics to the field of biomedicine, to expand and preserve autonomy and dignity of human beings. The Ethics Committee (EC) of Escola Superior de Saúde (ESS) was born in February 2011. The importance for this unit of P.PORTO in having such a committee, for ethical and not legal imperative, came ...
A importância das comissões de ética nas tecnologias da saúde: a experiência da...
Tavares, Diana; Amorim, Manuela; Cabral, Ana Paula; Cruz, Agostinho; Curado, Henrique; Faria, Isabel; Gonçalves, Maria João; Lopes, PaulaA Escola Superior de Saúde (ESS) do Instituto Politécnico do Porto (P.PORTO) completou recentemente o seu 40º aniversário de existência, enquanto instituição de ensino superior (IES) de referência na área da saúde. A evolução desta IES tem sido notória tanto ao nível da formação graduada, como pós-graduada, atividades de extensão à comunidade, onde se insere a recente Clínica Pedagógica, e criação de dois centr...