7 documents found, page 1 of 1
The transcription factor CgHaa1 plays a role in virulence of the pathogenic yea...
Salazar, Sara Barbosa; Pedro, Nuno Alexandre; Silva, Sónia Carina; Mil-Homens, Dalila; Pimenta, Andreia; Wlodarczyk, Marcin; Szwed-Georgiou, AleksandraCandida glabrata is a prominent causative agent of mucosal and disseminated human infections. Part of the success of C. glabrata as a human pathogen relies on its adherence capacity and ability to tolerate/surpass the activity of immune cells. Herein we describe the involvement of the transcription factor CgHaa1 and of its regulated genes CgAWP12, CgAWP13, CAGL0H07469 g, and CAGL0K10164 g in adherence of C. gla...
Vapor phase of white thyme essential oil: effect on Candida albicans and preser...
Fernandes, Liliana Sousa; Silva, Inês da; Araújo, Daniela Eira; Costa, Raquel Pinho; Silva, Sónia Carina; Mira, Nuno Pereira; Costa-de-Oliveira, SofiaThe balance of the vaginal ecosystem results from synergistic interactions established between the different colonizing microorganisms. Lactobacillus spp. stands out as a predominant member, acting a crucial protective role in maintaining vaginal health. As vulvovaginal candidiasis remains prevalent and antifungal resistance grows, there is a pressing need for alternative therapies. However, any development of ...
Assessing the ability of Lactobacillus strains to counteract enterotoxigenic Es...
Araújo, Daniela; Silva, Ana Rita; Oliveira, Ana; Mira, Nuno Pereira; Silva, Sónia Carina; Almeida, Carina; Castro, Joana Isabel ReisEnteric colibacillosis is a common disease in weanling pigs, with postweaning diarrhea (PWD) as the main symptom in piglets. It is caused by the colonization of the small intestine by enterotoxigenic strains of Escherichia coli (ETEC). Of the control strategies, antibiotics and zinc oxide have been the most effective in reducing the economic losses caused by PWD. However, concerns about antibiotic resistance ha...
Effect of progesterone on Candida albicans biofilm formation under acidic condi...
Gonçalves, Bruna; Bernardo, Ruben; Wang, Can; Schroeder, Markus; Pedro, Nuno A.; Butler, Geraldine; Azeredo, Joana; Henriques, MarianaVulvovaginal candidiasis (VVC) caused by Candida albicans is a common disease worldwide. A very important C. albicans virulence factor is its ability to form biofilms on epithelium and/or on intrauterine devices promoting VVC. It has been shown that VVC has a hormonal dependency and that progesterone affects virulence traits of C. albicans cells. To understand how the acidic environment (pH 4) and progesterone ...
Study of the activity of Punica granatum-mediated silver nanoparticles against ...
Souza, José António Santos [UNESP]; Alves, Marta M.; Barbosa, Debora Barros [UNESP]; Lopes, Maria Manuel; Pinto, Eugénia; Figueiral, Maria HelenaMade available in DSpace on 2020-12-12T02:09:26Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-06-01; The continuous emergence of Candida strains resistant to currently used antifungals demands the development of new alternatives that could reduce the burden of candidiasis. In this work silver nanoparticles synthesized using a green route are efficiently used, alone or in combination with fluconazole, a...
Characterizing the potential of the non-conventional yeast Saccharomycodes ludw...
Esteves, Marcos; Barbosa, Catarina; Vasconcelos, Isabel; Tavares, Maria João; Mendes-Faia, Arlete; Mira, Nuno Pereira; Mendes-Ferreira, AnaNon-Saccharomyces yeasts have received increased attention by researchers and winemakers, due to their particular contributions to the characteristics of wine. In this group, Saccharomycodes ludwigii is one of the less studied species. In the present study, a native S. ludwigii strain, UTAD17 isolated from the Douro wine region was characterized for relevant oenological traits. The genome of UTAD17 was recently...
The CgHaa1-regulon mediates response and tolerance to acetic acid stress in the...
Bernardo, Ruben T.; Cunha, Diana V.; Wang, Can; Pereira, L. P.; Silva, Sónia Carina; Salazar, Sara B.; Schröder, Markus S.; Okamoto, MichiyoTo thrive in the acidic vaginal tract C. glabrata has to cope with high concentrations of acetic acid. The mechanisms underlying C. glabrata tolerance to acetic acid at low pH remain largely uncharacterized. In this work it is demonstrated the essential role of the CgHaa1 transcription factor (encoded by ORF CAGL0L09339g) in the response and tolerance of C. glabrata to acetic acid. Transcriptomic analysis showe...