3 documents found, page 1 of 1
Polymorphisms of folate pathway enzymes (Methylenetetrahydrofolate reductase an...
Costa, Débora Menezes da; Lima, Germano Paulo Venceslau de; Faria, Mário Henrique Girão; Rabenhorst, Silvia Helena Baremwo important polymorphisms of folate cycle enzymes, methylenetetrahydrofolate reductase ( MTHFR) C677T and thymidylate synthase (TS) enhancer region (TSER) 28-bp tandem repeat, are related to risk of various types of cancer, including brain tumors, although there are few studies on this subject. A case–control study of these two polymorphisms in astrocytomas of different grades was carried out using polymerase ...
Central giant cell lesion of the jaws : study of CCND1 gene amplification and p...
Nogueira, Renato Luiz Maia; Faria, Mário Henrique Girão; Osterne, Rafael Lima Verde; Cavalcante, Roberta Barroso; Ribeiro, Ronaldo AlbuquerqueCentral giant cell lesions (CGCLs) are uncommon benign jaw lesions with uncertain etiology and a variable clinical behavior. In neoplasms, alterations in molecules involved in the G1/S checkpoint are frequently found. Loss of p16INK4a expression or overexpression of cyclin D1 may stimulate cell proliferation. The purpose of this study was to analyze CCND1 gene amplification and the expression of p16INK4a in CGC...
Estudo imuno-histoquímico das alterações moleculares nos tumores astrocíticos :...
Faria, Mário Henrique GirãoThe present study aimed to evaluate the expression of genes involved in the tumorigenic process and in the chemoresistance mechanisms of the astrocytic tumors. A clinical and epidemiological analysis, histopathological evaluation and immunohistochemical study of the proteins Ki-67, c-Myc, GFAP, p53, p21WAF1/CIP1, p27KIP1, Bcl-2, Bax, EGFR, erbB-2, p21Ras, MGMT, GSTπ, TS and TopoIIα using streptoavidin-biotin-pe...