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Improving the solubility of the antichagasic drug benznidazole through formatio...
Sobrinho,José Lamartine Soares; Soares,Mônica Felts de La Roca; Labandeira,Juan Jose Torres; Alves,Lariza Darlene Santos; Rolim Neto,Pedro JoséThis study describes unpublished research on improving the solubility of benznidazole by the formation of an inclusion complex. The cyclodextrins selected were αCD, βCD, γCD, HPβCD, RMβCD and SBβCD. All complexes were obtained in solution, presenting 1:1 stoichiometry according to the phase solubility diagram. The highest association constants were obtained with RMβCD and SBβCD, being selected for attainment of...
Desenvolvimento de método analítico para quantificação do efavirenz por espectr...
Alves,Lariza Darlene Santos; Rolim,Larissa Araújo; Fontes,Danilo Augusto Ferreira; Rolim-Neto,Pedro José; Soares,Mônica Felts de La RocaAn UV-Vis spectrophotometry analytical method for quantifying Efavirenz was developed and validated as an alternative to replace the HPLC current method. The report method presents sample concentration of 10 μg mL-1, dissolved in a solution ethanol:water (60:40, v/v), economic and technically adequate for the purpose adopted. The results and the statistical treated proved that the method being considered an pre...
Development of new dissolution test and HPLC-RP method for anti-parasitic ornid...
Soares,Mônica Felts de La Roca; Soares Sobrinho,José Lamartine; Grangeiro Júnior,Severino; Silva,Keyla Emanuelle Ramos da; Alves,Lariza Darlene SantosThis work aimed the development and validation of a new dissolution test for ornidazole coated tablets. The dissolution conditions were determined after testing Sink conditions, dissolution medium, apparatus, stirring speed, 24 h stability and medium filtration influence. The best conditions were paddle at a stirring speed of 75 rpm and 900 mL of 0.1 M HCl. A new HPLC quantification method was developed and val...