12 documents found, page 1 of 2

An Approach to Estimate Electric Vehicle Driving Range

The use of electric vehicle (EV) has grown rapidly over the past few years. The EV is now accepted as a reliable and eco-friendly means of transportation. When choosing an EV, usually one of the key parameters of choice for the customer is its driving range (DR) capability. This is a decisive factor since it minimizes the drivers anxiety on a trip. The DR depends on many factors that must be taken into account ...

Influence of TFAP2B and KCTD15 genetic variability on personality dimensions in...

Introduction: TFAP2B and KCTD15 are obesity-related genes that interact to regulate feeding behavior. We hypothesize that variability in these loci, isolated or in combination, could also be related to the risk of eating disorders (ED) and/or associated psychological traits. Methods: We screened 425 participants (169 ED patients, 75 obese subjects, and 181 controls) for 10 clinically relevant and tag single-nuc...

The contribution of genetics and environment to obesity

Background: Obesity is a global health problem mainly attributed to lifestyle changes such as diet, low physical activity or socioeconomics factors. However, several evidences consistently showed that genetics contributes significantly to the weight-gain susceptibility. Sources of data: A systematic literature search of most relevant original, review and meta-analysis, restricted to English was conducted in Pub...

Current review of genetics of human obesity: from molecular mechanisms to an ev...

RNA Interference Mitigates Motor and Neuropathological Deficits in a Cerebellar...

Machado-Joseph disease or Spinocerebellar ataxia type 3 is a progressive fatal neurodegenerative disorder caused by the polyglutamine-expanded protein ataxin-3. Recent studies demonstrate that RNA interference is a promising approach for the treatment of Machado-Joseph disease. However, whether gene silencing at an early time-point is able to prevent the appearance of motor behavior deficits typical of the dise...

Association study of common polymorphisms in MSRA, TFAP2B, MC4R, NRXN3, PPARGC1...

Novel Variants in theMC4RandLEPRGenes among Severely Obese Children from the Ib...

Silencing mutant ataxin-3 rescues motor deficits and neuropathology in Machado-...

Machado-Joseph disease (MJD) or spinocerebellar ataxia type 3 (SCA3) is an autosomal dominantly-inherited neurodegenerative disorder caused by the over-repetition of a CAG codon in the MJD1 gene. This expansion translates into a polyglutamine tract that confers a toxic gain-of-function to the mutant protein--ataxin-3, leading to neurodegeneration in specific brain regions, with particular severity in the cerebe...

Distribution of the − 13910C>T polymorphism in the general population of Portug...

Association of FTO Polymorphisms with Obesity and Obesity-Related Outcomes in P...