4 documents found, page 1 of 1
Efeitos da Terapia com Anti-TNF alfa na Pressão Arterial em Pacientes com Hiper...
Faria,Ana Paula de; Ritter,Alessandra M. V.; Santa-Catharina,Arthur; Souza,Débora P.; Naseri,Estephania P.; Bertolo,Manoel B.; Pioli,Mariana RodriguesResumo Fundamento: A citocina fator de necrose tumoral alfa (TNF-α) é elevada na hipertensão resistente (HAR), mas os efeitos dos inibidores de TNF-α nessa população ainda são desconhecidos. Objetivos: O objetivo deste estudo foi avaliar se uma única dose de infliximabe controlada por placebo reduz a pressão arterial (PA) de forma aguda em pacientes com HAR. Métodos: Realizamos um estudo cruzado, randomizado, d...
A Proposed Inflammatory Score of Circulating Cytokines/Adipokines Associated wi...
Faria,Ana Paula de; Ritter,Alessandra Mileni Versuti; Gasparetti,Carolina Souza; Corrêa,Nathália Batista; Brunelli,Veridiana; Almeida,AurélioAbstract Background: There is evidence that subclinical systemic inflammation is present in resistant hypertension (RHTN). Objective: The aim of the study was to develop an integrated measure of circulating cytokines/adipokines involved in the pathophysiology of RHTN. Methods: RHTN (n = 112) and mild to moderate hypertensive (HTN) subjects (n=112) were studied in a cross-sectional design. Plasma cytokines/adipo...
Metabolic Syndrome-Related Features in Controlled and Resistant Hypertensive Su...
Catharina,Arthur Santa; Modolo,Rodrigo; Ritter,Alessandra Mileni Versuti; Sabbatini,Andréa Rodrigues; Lopes,Heno Ferreira; Moreno Junior,HeitorAbstract Background: Metabolic syndrome (MetS) is widespread among hypertensive patients. Clinical features and potential biomarkers of MetS in the presence of hypertension and resistant hypertension (RHTN) represent a great area of interest for investigation. Objective: The purpose of this study was to evaluate the prevalence of MetS and the clinical features associated with it in resistant and mild to moderat...
Role Of MMP-2 and MMP-9 in Resistance to Drug Therapy in Patients with Resistan...
Lacerda,Leandro; Faria,Ana Paula de; Fontana,Vanessa; Moreno,Heitor; Sandrim,ValériaAbstract Background: Despite the increased evidence of the important role of matrix metalloproteinases (MMP-9 and MMP‑2) in the pathophysiology of hypertension, the profile of these molecules in resistant hypertension (RHTN) remains unknown. Objectives: To compare the plasma levels of MMP-9 and MMP-2 and of their tissue inhibitors (TIMP-1 and TIMP-2, respectively), as well as their MMP-9/TIMP-1 and MMP-2/TIMP-2...