4 documents found, page 1 of 1
The human pandemic coronaviruses on the show: the spike glycoprotein as the mai...
Souza, Pedro F. N.; Mesquita, Felipe P.; Amaral, Jackson Lima; Landima, Patrícia G. C.; Lima, Karollyny R. P.; Costa, Marília B.; Farias, Izabelle RochaThree coronaviruses (CoVs) have threatened theworld population by causing outbreaks in the last two decades. In late 2019, the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emerged and caused the coronaviruses to disease 2019 (COVID-19), leading to the ongoing global outbreak. The other pandemic coronaviruses, SARS-CoV and Middle East respiratory syndrome CoV (MERS-CoV), share a considerable leve...
Analise da expressão dos genes de reparo da lesão de fita dupla do DNA de traba...
Farias, Izabelle RochaThe need to increase the demand for food produced brought with it an incorporation of technical-scientific development in agriculture and became a justification for the use of some chemicals in order to obtain a higher production through the manipulation of organic factors. The damage caused by high levels of toxicity of pesticides in a greater number of cases of cancers in farmers, making studies of the mechan...
New polymorphisms of Xeroderma Pigmentosum DNA repair genes in myelodysplastic ...
Santiago, Sabrina Pinheiro; Ribeiro Junior, Howard Lopes; Sousa, Juliana Cordeiro de; Borges, Daniela de Paula; Oliveira, Roberta Taiane Germano deThe association between Xeroderma Pigmentosum DNA repair genes ( XPA rs1800975, XPC rs2228000, XPD rs1799793 and XPF rs1800067) polymorphisms and myelodysplastic syndrome (MDS) have not been reported. To assess the functional role between these polymorphisms and MDS, we evaluated 189 sam- ples stratified in two groups: 95 bone marrow samples from MDS patients and 94 from healthy elderly volunteers used as contr...
DNA repair gene expressions are related to bone marrow cellularity in myelodysp...
Ribeiro Jr., Howard L.; Maia, Allan Rodrigo S.; Oliveira, Roberta Taiane G. de; Costa, Marília Braga; Farias, Izabelle Rocha; Borges, Daniela de PaulaObjective To evaluate the expression of genes related to nuclear excision (ERCC8, XPA and XPC), homologous recombination and non-homologous end-joining (ATM, BRCA1, BRCA2 and LIG4) repair mechanisms, using quantitative PCR methodologies, and it relation with bone marrow cellularity in myelodysplastic syndrome (MDS). Methods and results A total of 51 adult de novo patients with MDS (3 refractory anaemia (RA), 11...