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Real-World Effectiveness and Safety of Dupilumab, Tralokinumab, and Upadacitini...

Torres, Tiago; Yeung, Jensen; Prajapati, Vimal H.; Ribero, Simone; Balato, Anna; Marzano, Angelo Valerio; Cruz, Maria João; Paiva-Lopes, Maria

Introduction: Evaluating the real-world effectiveness, safety, and tolerability of targeted biologic and non-biologic therapies in patients with atopic dermatitis (AD) treated in routine clinical practice remains crucial. In this international, multicenter, retrospective, comparative study we aimed to evaluate the 52-week effectiveness, safety, and tolerability of dupilumab, tralokinumab, and upadacitinib in pa...


The portuguese severe asthma registry : development, features, and data sharing...

Sousa, Ana Sá; Fonseca, João Almeida; Pereira, Ana Margarida; Ferreira, Ana; Arrobas, Ana; Mendes, Ana; Drummond, Marta; Videira, Wanda; Costa, Tiago

The Portuguese Severe Asthma Registry (Registo de Asma Grave Portugal, RAG) was developed by an open collaborative network of asthma specialists. RAG collects data from adults and pediatric severe asthma patients that despite treatment optimization and adequate management of comorbidities require step 4/5 treatment according to GINA recommendations. In this paper, we describe the development and implementation ...


Web-assisted laboratory for control education : remote and virtual environments

Leão, Celina Pinto; Soares, Filomena; Rodrigues, Helena; Seabra, Eurico; Machado, José Mendes; Farinha, Pedro; Costa, Sandra

The Web Assisted Laboratory for Control (WALC) engineering on- line education is described. This on-line platform was developed by a multidisciplinary team. WALC enables the access to several virtual and remote labora- tories experiences on automation, process control and numerical methods. The virtual environment enables the registered user to test different control systems (hydraulic, mechanical, electrical) ...


How to securely break into RBAC: the BTG-RBAC model

Ferreira, Ana; Chadwick, David; Zao, Gansen; Farinha, Pedro; Correia, Ricardo; Chilro, Rui; Antunes, Luís

Access control models describe frameworks that dictate how subjects (e.g. users) access resources. In the Role-Based Access Control (RBAC) model access to resources is based on the role the user holds within the organization. RBAC is a rigid model where access control decisions have only two output options: Grant or Deny. Break The Glass (BTG) policies on the other hand are flexible and allow users to break or ...


Histiocitose de células de langerhans: um estudo de 20 casos

Vinhais, Sofia; Farinha, Pedro; Cunha, Teresa Margarida

Objectivo: Descrever os aspectos clínico-radiológicos da Histiocitose de Células de Langerhans (HCL) numa série de doentes. Material e Métodos: Reviram-se 20 casos de HCL, nove com diagnóstico segundo os actuais critérios anátomo-patológicos (positividade para CD1a e/ou presença de grânulos de Birbeck em microscopia electrónica), outros nove apenas com critérios morfológicos, e dois casos com diagnóstico patoló...


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