2 documents found, page 1 of 1
Polymorphisms in the CIITA −168A/G (rs3087456) and CIITA +1614G/C (rs4774) may ...
Pereira,Valéria Coelho Santa Rita; Fontes-Dantas,Fabrícia Lima; Paradela,Eduardo Ribeiro; Malfetano,Fabíola RachidABSTRACT It is currently unknown how genetic factors may influence the clinical course of multiple sclerosis (MS). Objective: We examined the impact of CIITA polymorphisms −168A/G (rs3087456) and +1614G/C (rs4774) on the risk of disability progression, severity and on responses to first-line immunomodulator treatments. Methods: Genomic DNA was extracted from blood samples. We used ABI3730xl and GeneMapper v.4.0...
Increased multiple sclerosis relapses related to lower prevalence of pain
Silva,José Vinícius Martins da; Oliveira,Beatriz Fátima Alves de; Nascimento,Osvaldo José Moreira do; Farinhas,João Gabriel DibObjective The study aims to investigate the presence of pain amongst multiple sclerosis (MS) patients. Method One hundred MS patients responded to questionnaires evaluating neuropathic and nociceptive pain, depression and anxiety. Statistical analysis was performed using the Mann–Whitney U, Chi-Square and two-tailed Fisher’s exact tests and multivariate logistic regression. Results Women had a statistically hig...