7 documents found, page 1 of 1
Evolutionary history and functional characterization of duplicated G protein-co...
Zapater, Cinta; Moreira, Catarina; Knigge, Thomas; Monsinjon, Tiphaine; Gómez, Ana; Pinto, Patricia I. S.Across vertebrates, the numerous estrogenic functions are mainly mediated by nuclear and membrane receptors, including the G protein-coupled estrogen receptor (GPER) that has been mostly associated with rapid non-genomic responses. Although Gper-mediated signalling has been characterized in only few fish species, Gpers in fish appear to present more mechanistic functionalities as those of mammals due to additio...
The influence of 17β-oestradiol on lymphopoiesis and immune system ontogenesis ...
Moreira, Catarina; Paiola, Matthieu; Duflot, Aurélie; Varó, Inma; Sitjà-Bobadilla, Ariadna; Knigge, Thomas; Pinto, P; Monsinjon, TiphaineThe female sex steroid 17β-oestradiol (E2) is involved in the regulation of numerous physiological functions, including the immune system development and performance. The role of oestrogens during ontogenesis is, however, not well studied. In rodents and fish, thymus maturation appears to be oestrogen-dependent. Never theless, little is known about the function of oestrogen in immune system development. To furt...
Proteomic changes in the extracellular environment of sea bass thymocytes expos...
Moreira, Catarina; Hétru, Julie; Paiola, Matthieu; Duflot, Aurélie; Chan, Philippe; Vaudry, David; Monsinjon, Tiphaine; Knigge, ThomasThe thymus is an important immune organ providing the necessary microenvironment for the development of a diverse, self-tolerant T cell repertoire, which is selected to allow for the recognition of foreign antigens while avoiding self-reactivity. Thymus function and activity are known to be regulated by sex steroid hormones, such as oestrogen, leading to sexual dimorphisms in immunocompetence between males and ...
Prepubertal gonad investment modulates thymus function: evidence in a teleost fish
Paiola, Matthieu; Moreira, Catarina; Hétru, Julie; Duflot, Aurélie; Pinto, Patrícia; Scapigliati, Giuseppe; Knigge, Thomas; Monsinjon, TiphaineThymus plasticity following gonadectomy or sex hormone replacement has long since exemplified sex hormone effects on the immune system in mammals and, to a lesser extent, in 'lower vertebrates', including amphibians and fish. Nevertheless, the underlying physiological significances as well as the ontogenetic establishment of this crosstalk remain largely unknown. Here, we used a teleost fish, the European sea b...
Developmental immunotoxicology: What underlies the critical windows of exposure?
Moreira, Catarina; Paiola, Matthieu; Duflot, Aurelie; del Pozo, Raquel; Carla Piazzon, M.; Fouz, Belen; Varo, Inma; Sitja-Bobadilla, AriadnaEndocrine disruptors in general and oestrogenic compounds in particular have been widely investigated in view of their effects on several physiological processes and, therefore, their ecotoxicologic relevance. The modulation of the immune system by oestrogens has increasingly sparked interest in the research community, that previously had been mainly centered on the reproductive effects of these hormones. In fa...
Oestrogen, an evolutionary conserved regulator of T cell differentiation and im...
Paiola, Matthieu; Knigge, Thomas; Duflot, Aurélie; Pinto, Patricia IS; Farcy, Emilie; Monsinjon, TiphaineIn teleosts, as in mammals, the immune system is tightly regulated by sexual steroid hormones, such as oestrogens. We investigated the effects of 17β-oestradiol on the expression of several genes related to T cell development and resulting T cell subpopulations in sea bass, Dicentrarchus labrax, for a primary lymphoid organ, the thymus, and two secondary lymphoid organs, the head-kidney and the spleen. In paral...
Oestrogen receptor distribution related to functional thymus anatomy of the Eur...
Paiola, Matthieu; Knigge, Thomas; Picchietti, Simona; Duflot, Aurelie; Guerra, Laura; Pinto, Patricia IS; Scapigliati, Giuseppe; Monsinjon, TiphaineIn jawed vertebrates, the crosstalk between immune and endocrine system as well as many fundamental mechanisms of T cell development are evolutionary conserved. Oestrogens affect mammalian thymic function and plasticity, but the mechanisms of action and the oestrogen receptors involved remain unclear. To corroborate the oestrogenic regulation of thymic function in teleosts and to identify the implicated oestrog...