24 documents found, page 1 of 3
Portuguese Recommendations for the Use of Biological and Targeted Synthetic Dis...
Fernandes, BM; Guimarães, F; Almeida, DE; Neto, A; Tavares-Costa, J; Roxo Ribeiro, A; Quintal, A; Pereira, JP; Silva, L; Nóvoa, TS; Faustino, A; Vaz, CObjective: To update the recommendations for the treatment of rheumatoid arthritis (RA) with biological and targeted synthetic disease-modifying antirheumatic drugs (bDMARDs and tsDMARDs), endorsed by the Portuguese Society of Rheumatology (SPR). Methods: These treatment recommendations were formulated by Portuguese rheumatologists taking into account previous recommendations, new literature evidence and consen...
Portuguese recommendations for the use of biological and targeted synthetic dis...
Fernandes, Bruno Miguel; Guimarães, F; Almeida, DE; Neto, A; Tavares-Costa, J; Ribeiro, AR; Quintal, Alberto; Pereira, JP; Silva, L; Nóvoa, TSObjective: To update the recommendations for the treatment of rheumatoid arthritis (RA) with biological and targeted synthetic disease-modifying antirheumatic drugs (bDMARDs and tsDMARDs), endorsed by the Portuguese Society of Rheumatology (SPR). Methods: These treatment recommendations were formulated by Portuguese rheumatologists taking into account previous recommendations, new literature evidence and consen...
A mouse model reproducing the pathophysiology of neonatal group B streptococcal...
Andrade, EB; Magalhães, A; Puga, A; Costa, M; Bravo, J; Portugal, CC; Ribeiro, A; Correia-Neves, M; Faustino, A; Firon, A; Trieu-Cuot, P; Summavielle, TGroup B streptococcal (GBS) meningitis remains a devastating disease. The absence of an animal model reproducing the natural infectious process has limited our understanding of the disease and, consequently, delayed the development of effective treatments. We describe here a mouse model in which bacteria are transmitted to the offspring from vaginally colonised pregnant females, the natural route of infection. ...
Common evaluations of disease activity in rheumatoid arthritis reach discordant...
Canhão, H; Rodrigues, AM; Gregório, Maria João; Dias, SS; Gomes, JAM; Santos, MJ; Faustino, A; Costa, JA; Allaart, C; Gvozdenovic, E; van der Heijde, DObjectives: The classification of disease activity states in rheumatoid arthritis (RA) can be achieved through disease activity indices, such as the Disease Activity Score in 28 joints erythrocyte sedimentation rate (DAS28-ESR), the Simplified Disease Activity Index (SDAI), and the Clinical Disease Activity Index (CDAI). Subjective measurements, such as patient reported outcomes have been incorporated into seve...
Endocardite Infecciosa: Casuística do Departamento de Medicina Interna de um Ho...
Melo, L; Duarte, J; Roque, D; Oliveira, I; Faustino, A; Caetano, J; Oliveira, SIntrodução: Apesar da evolução das características epidemio- lógicas, a endocardite infecciosa mantém uma mortalidade e morbilidade significativas. Tem havido um aumento da incidên- cia em idades avançadas e sem os factores de risco clássicos. Este trabalho procura caracterizar os doentes internados por endocardite infecciosa nos serviços de Medicina Interna de um hospital da região de Lisboa, num período de se...
Síndrome febril indeterminada: uma causa rara
Araújo, M; Espadinha, V; Faustino, A; Carvalho, F; Louro, F
Poly-N-acetylglucosamine production by Staphylococcus epidermidis cells increas...
Ferreirinha, P; Pérez-Cabezas, B; Correia, A; Miyazawa, B; França, A; Carvalhais, V; Faustino, A; Cordeiro-da-Silva, A; Teixeira, L; Pier, G; Cerca, NPoly-N-acetylglucosamine (PNAG) is a major component of the Staphylococcus epidermidis biofilm extracellular matrix. However, it is not yet clear how this polysaccharide impacts the host immune response and infection-associated pathology. Faster neutrophil recruitment and bacterial clearance were observed in mice challenged intraperitoneally with S. epidermidis biofilm cells of the PNAG-producing 9142 strain th...
Abordagem do delírium no doente crítico
Faustino, AO delirium consiste num síndrome confusional agudo com grande impacto na morbimortalidade dos doentes, apresentando uma prevalência elevada na UCI. É importante diagnosticar precocemente esta situação clínica, de modo a obter melhores cuidados de saúde. Para a sua identificação têm surgido várias escalas de avaliação, sendo a CAM-ICU e a ICDSC as que mostraram maior evidência na sua validação. Na avaliação dos ...
The Portuguese Society of Rheumatology position paper on the use of biosimilars
Fonseca, JE; Gonçalves, J; Araújo, F; Cordeiro, I; Teixeira, F; Canhão, H; Pereira da Silva, JA; Garcês, S; Miranda, LC; Ramiro, Sofia; Roxo, AnaBiotechnological drugs have become a fundamental resource for the treatment of rheumatic patients. Patent expiry of some of these drugs created the opportunity for biopharmaceutical manufacturers to develop biosimilar drugs intended to be as efficacious as the originator product but with a lower cost to healthcare systems. Due to the complex manufacturing process and highly intricate structure of biologicals, a...
Can cardiac computed tomography predict cardiovascular events in asymptomatic t...
Faustino, A; Providência, R; Mota, P; Barra, S; Silva, J; Fernandes, A; Catarino, R; Basso, S; Costa, M; Leitão-Marques, ABACKGROUND: Doubts remain about atherosclerotic disease and risk stratification of asymptomatic type-2 diabetic patients (T2DP). This study aims to evaluate the usefulness of calcium score (CS) and coronary computed tomography (CT) angiography (CTA) to predict fatal and non fatal cardiovascular events (CVEV) in T2DP. METHODS: Eighty-five consecutive T2DP undergoing CT (Phillips Brilliance, 16-slice) with CS and...