3 documents found, page 1 of 1
Confirmatory assays for transient changes of omics in soil invertebrates - copp...
Bicho, Rita C.; Faustino, A. M. R.; Rêma, A.; Scott-Fordsmand, Janeck J.; Amorim, Mónica J. B.Environmental risk assessment (ERA) based on effects caused by chronic and longer term exposure is highly relevant. Further, if mechanistic based approaches (e.g. omics) can be included, beyond apical endpoints (e.g. reproduction), the prediction of effects increases. For Cu NMs (and CuCl2) this has been studied in detail, covering multi-omics and apical effects using the soil standard species Enchytraeus crypt...
Analysis of the immune response to Neospora caninum in a model of intragastric ...
Teixeira, L.; Botelho, A. S.; Batista, A. R.; Meireles, C. S.; Ribeiro, A.; Domingues, H. S.; Correia Da Costa, J. M.; Castro, António G.To study experimental Neospora caninum infection initiated at the gastrointestinal tract, Toll-like Receptor 4- and functional IL-12Rbeta2 chain-deficient C57BL/10 ScCr mice were challenged intragastrically with 5 x 10(6) N. caninum tachyzoites. All parasite-inoculated mice eventually died with disseminated infection. In contrast, immunocompetent BALB/c mice challenged with 1 x 10(7) N. caninum tachyzoites by t...
Neospora caninum: high susceptibility to the parasite in C57BL/10ScCr mice
Botelho, A. S.; Teixeira, L.; Costa, J. M. Correia da; Faustino, A. M. R.; Castro, António G.; Vilanova, M.C57BL/10ScCr mice, lack Toll-like receptor 4 and a functional Interleukin-12 receptor. Taking this into account, susceptibility of these mice to Neospora caninum infection was assessed comparatively to that of immunocompetent C57BL/10ScSn mice. C57BL/10ScCr mice inoculated intraperitoneally with 5 x 10(5) N. caninum tachyzoites showed a high Susceptibility to this parasite. All infected C57BL/10ScCr mice were d...