9 documents found, page 1 of 1
Common Evaluations of Disease Activity in Rheumatoid Arthritis Reach Discordant...
Canhão, Helena; Rodrigues, Ana Maria; Gregório, Maria João; Dias, Sara S; Melo Gomes, José António; Santos, Maria José; Faustino, AugustoObjectives: The classification of disease activity states in rheumatoid arthritis (RA) can be achieved through disease activity indices, such as the Disease Activity Score in 28 joints erythrocyte sedimentation rate (DAS28-ESR), the Simplified Disease Activity Index (SDAI), and the Clinical Disease Activity Index (CDAI). Subjective measurements, such as patient reported outcomes have been incorporated into seve...
A mouse model reproducing the pathophysiology of neonatal group B streptococcal...
Bonifácio Andrade, Elva; Magalhães, Ana; Puga, Ana; Costa, Madalena; Bravo, Joana; Portugal, Camila Cabral; Ribeiro, Adília; Correia-Neves, MargaridaGroup B streptococcal (GBS) meningitis remains a devastating disease. The absence of an animal model reproducing the natural infectious process has limited our understanding of the disease and, consequently, delayed the development of effective treatments. We describe here a mouse model in which bacteria are transmitted to the offspring from vaginally colonised pregnant females, the natural route of infection. ...
A mouse model reproducing the pathophysiology of neonatal group B streptococcal...
Andrade, Elva Bonifácio; Magalhães, Ana; Puga, Ana; Costa, Madalena; Bravo, Joana; Portugal, Camila Cabral; Ribeiro, Adília; Correia-Neves, MGroup B streptococcal (GBS) meningitis remains a devastating disease. The absence of an animal model reproducing the natural infectious process has limited our understanding of the disease and, consequently, delayed the development of effective treatments. We describe here a mouse model in which bacteria are transmitted to the offspring from vaginally colonised pregnant females, the natural route of infection. ...
Common evaluations of disease activity in rheumatoid arthritis reach discordant...
Canhão, Helena; Rodrigues, Ana Maria; Gregório, Maria João; Dias, Sara Simões; Melo Gomes, José António; Santos, Maria José; Faustino, AugustoThe classification of disease activity states in rheumatoid arthritis (RA) can be achieved through disease activity indices, such as the Disease Activity Score in 28 joints erythrocyte sedimentation rate (DAS28-ESR), the Simplified Disease Activity Index (SDAI), and the Clinical Disease Activity Index (CDAI). Subjective measurements, such as patient reported outcomes have been incorporated into several of these...
Reuma.pt – a case study
Santos, Maria J; Canhão, Helena; Faustino, Augusto; Fonseca, João Euricon/a; n/a
Endocrine disruption effects of p,p'-DDE on juvenile zebrafish
Monteiro, Marta Sofia; Pavlaki, Maria; Faustino, Augusto; Rêma, Alexandra; Franchi, Mariana; Gediel, Letícia; Loureiro, Susana; Domingues, InêsThe persistent organic pollutant p,p′-DDE, the major metabolite of the insecticide DDT, has displayed evidence of endocrine disruption through the inhibition of androgen binding to androgen receptors in different species. Although p,p′-DDE was continuously detected in wild fish with abnormal gonad development such as intersex, little is known about its mode of action during gonad development in fish. To elucida...
Participation of Candida albicans transcription factor Rlm1 in cell wall biogen...
Silva, Yolanda Bedsabé Delgado; Vaz, Catarina Oliveira; Pereira, Joana Carvalho; Carneiro, Catarina; Nogueira, Eugénia Sofia Costa; Correia, AlexandraCandida albicans cell wall is important for growth and interaction with the environment. RLM1 is one of the putative transcription factors involved in the cell wall integrity pathway, which plays an important role in the maintenance of the cell wall integrity. In this work we investigated the involvement of RLM1 in the cell wall biogenesis and in virulence. Newly constructed C. albicans Δ/Δrlm1 mutants showed t...
Participation of Candida albicans transcription factor RLM1 in cell wall biogen...
Delgado-Silva, Yolanda; Vaz, Catarina; Carvalho-Pereira, Joana; Carneiro, Catarina; Nogueira, Eugénia; Correia, Alexandra; Carreto, Laura; Silva, SóniaCandida albicans cell wall is important for growth and interaction with the environment. RLM1 is one of the putative transcription factors involved in the cell wall integrity pathway, which plays an important role in the maintenance of the cell wall integrity. In this work we investigated the involvement of RLM1 in the cell wall biogenesis and in virulence. Newly constructed C. albicans Δ/Δrlm1 mutants showed t...
The usefulness of mesocosms for ecotoxicity testing with lacertid lizards
Amaral, Maria José; Bicho, Rita C.; Carretero, Miguel A.; Sanchez-Hernandez, Juan C.; Faustino, Augusto; Soares, Amadeu M. V. M.; Mann, Reinier M.Mesocosms (i.e., outdoor, man-made representations of natural ecosystems) have seldom been used to study the impact of contaminants on terrestrial ecosystems. However, mesocosms can be a useful tool to provide a link between field and laboratory studies. We exposed juvenile lacertid lizards for a period of over one year to pesticides (herbicides and insecticides) in mesocosm enclosures with the intention of val...