15 documents found, page 1 of 2
The Impact of a Western Diet and Resistance Training in a Rat Model of Mammary ...
Silva, Jessica; Ferreira, Rita; Neuparth, Maria J.; Seixas, Fernanda; Ginja, Mário; Pires, Maria J.; Faustino-Rocha, Ana I.; Duarte, José AlbertoThis study aimed to investigate the impact of a Western diet and resistance training on cardiac remodeling in a rat model of chemically induced mammary cancer. Fifty-six female Wistar rats were randomly assigned to one of eight experimental groups, evaluating the impact of Western and standard diets, exercise and sedentarism, and the induction of mammary cancer. Mammary cancer was induced via the intraperitonea...
Exploring the therapeutic potential of Quercus ilex acorn extract in papillomav...
Medeiros-Fonseca, Beatriz; Faustino-Rocha, Ana I.; Pires, Maria João; Neuparth, Maria João; Vala, Helena; Nóbrega, Carmen; Gouvinhas, IreneBackground and Aim: Papillomaviruses (PVs) infections have been documented in numerous animal species across different regions worldwide. They often exert significant impacts on animal health and livestock production. Scientists have studied natural products for over half a century due to their diverse chemical composition, acknowledging their value in fighting cancer. Acorns (Quercus ilex) are believed to have...
Aloysia citrodora extract as a chemopreventive agent against HPV16-induced lesi...
Medeiros-Fonseca, Beatriz; Faustino-Rocha, Ana I.; Silva, Jéssica; Silva, Mónica G.; Pires, Maria João; Neuparth, Maria João; Vala, HelenaAim: Aloysia citrodora has a long history of traditional use in treating various ailments. This study evaluated the in vivo chemopreventive efficacy and systemic toxicity of an extract of A. citrodora in a transgenic mouse model of HPV16 (human papillomavirus type 16)-induced cancer. Methods: The experiment involved six groups (n = 5): group 1 (G1, wild-type (WT), water), group 2 (G2, HPV, water), group 3 (G3, ...
Ensino da Miologia Veterinária: do modelo ao cadáver
Lança, Maria João; Faustino-Rocha, Ana I.A Anatomia é a ciência que estuda a forma, a estrutura, a disposição e as relações das estruturas que constituem o organismo. A palavra “Anatomia” deriva do termo grego “Anatome”, formado por “Ana” que significa “em partes” e “tome” que significa “corte”. Se é correto que a Morfologia do organismo animal se mantém, de certo modo, inalterada nos seus conceitos fundamentais e na descrição geral dos sistemas e apa...
Anatomia e Fisiologia: evoluindo de “mãos dadas”
Faustino-Rocha, Ana I.; Lança, Maria JoãoA Anatomia e a Fisiologia encontram-se intimamente ligadas e são unidades curriculares fundamentais em inúmeros cursos ligados às ciências da vida. Documentos ancestrais comprovam que a história da Anatomia e da Fisiologia teve início na Grécia e encontra-se associada a Hipócrates (460-370 a.C.), conhecido como o Pai da Medicina, e à sua obra “Corpus Hippocraticus”. O médico grego Claudius Galeno (129-200 d.C.)...
Appraising Animal Models of Prostate Cancer for Translational Research: Future ...
Nascimento Gonçalves, Elisabete; Seixas, Fernanda; Da Costa, Rui M. Gil; Pires, Maria Joao; Neuparth, Maria Joao; Moreira-Goncalves, DanielThe growing incidence of prostate cancer has prompted a great investment in basic biology and translational studies to develop new therapies. Multiple animal models have been established to study etiological factors, cancer-preventive strategies and the molecular determinants of aggressiveness and metastases. The rat model of prostate cancer induced by chemical carcinogen N-methyl-N-nitrosourea (MNU) and testos...
Pulegone and Eugenol Oral Supplementation in Laboratory Animals: Results from A...
Ribeiro-Silva, CM; Faustino-Rocha, Ana I.; Gil da Costa, RM; Medeiros, R; Pires, MJ; Gaivão, I; Gama, A; Neuparth, MJ; Barbosa, JV; Peixoto, FEssential oils are natural compounds used by humans for scientific purposes due to their wide range of properties. Eugenol is mostly present in clove oil, while pulegone is the main constituent of pennyroyal oil. To guarantee the safe use of eugenol and pulegone for both humans and animals, this study addressed, for the first time, the effects of these compounds, at low doses (chronic toxicity) and high doses (...
Effects of testosterone and exercise training on bone microstructure of rats
Jota-Baptista, Catarina; Faustino-Rocha, Ana I.; Fardilha, Margarida; Ferreira, Rita; Oliveira, Paula A; Regueiro-Purriños, MartaMale hypogonadism results from failure to produce physiological levels of testosterone. Testosterone in men is essential in masculine development, sperm production, and adult man's health. Osteoporosis is one of the consequences of hypogonadism. Regular physical exercise and exogenous testosterone administration are frequently used to prevent or treat this condition. This study aimed to understand the effects o...
Virtual Physiology: A Tool for the 21st Century
Nóbrega, Carmen; Aires Pereira, Maria; Coelho, Catarina; Brás, Isabel; Mega, Cristina; Santos, Carla; Esteves, Fernando; Cruz, RitaVeterinary physiology is a basic curricular unit for every course within the veterinary field. It is mandatory to understand how the animal body works, and what to expect of a healthy body, in order to recognize any misfunction, and to be able to treat it. Classic physiology teaching involves wet labs, much equipment, many reagents, some animals, and a lot of time. But times are changing. In the 21st century, i...
Histopathological features of organs in a rat model of mamamry carcinogenesis: ...
Vala, Helena; Nóbrega, Carmen; Gama, Adelina; Ferreira, Rita; Oliveira, Paula A.; Faustino-Rocha, Ana I.Mammary tumors’ development was induced through the intraperioneal administration of the carcinogen N-methyl-N-nitrosourea (MNU). Animals from group control were injected with the vehicle (saline solution). Animals were sacrificed at 25 weeks-old and the organs were histopathologically evaluated. A higher number of lesions was observed in the organs of animals from group MNU. The animals from group control did ...