29 documents found, page 1 of 3
Paracoccidioides HSP90 can be found in the cell surface and is a target for ant...
Moura, Ágata Nogueira D’Áurea; Oliveira, Diane Sthefany Lima de; Paredes, Verenice; Rocha, Letícia Barboza; Oliveira, Fabiana Freire Mende deParacoccidioidomycosis (PCM) is one of the most frequent systemic mycoses in Latin America. It affects mainly male rural workers in impoverished regions, and the therapy can last up to two years or use drugs that are very toxic. Given the need for novel safe and effective approaches to treat PCM, we have been developing monoclonal antibodies (mAbs) that could be used not only to block specific fungal targets, b...
Faster cryptococcus melanization increases virulence in experimental and human ...
Sousa, Herdson Renney de; Oliveira Júnior, Getúlio Pereira de; Frazão, Stefânia de Oliveira; Gorgonha, Kaio César de Melo; Rosa, Camila PereiraCryptococcus spp. are human pathogens that cause 181,000 deaths per year. In this work, we systematically investigated the virulence attributes of Cryptococcus spp. clinical isolates and correlated them with patient data to better understand cryptococcosis. We collected 66 C. neoformans and 19 C. gattii clinical isolates and analyzed multiple virulence phenotypes and host–pathogen interaction outcomes. C. neofo...
Laccase affects the rate of Cryptococcus neoformans nonlytic exocytosis from ma...
Frazão, Stefânia de Oliveira; Sousa, Herdson Renney de; Silva, Lenise Gonçalves da; Folha, Jéssica dos Santos; Gorgonha, Kaio César de MeloNonlytic exocytosis is a process in which previously ingested microbes are expelled from host phagocytes with the concomitant survival of both cell types. This process has been observed in the interaction of Cryptococcus spp. and other fungal cells with phagocytes as distant as mammalian, bird, and fish macrophages and ameboid predators. Despite a great amount of research dedicated to unraveling this process, t...
Paracoccidioides HSP90 can be found in the cell surface and is a target for ant...
Moura, Ágata Nogueira D’Áurea; Oliveira, Diane Sthefany Lima de; Paredes, Verenice; Rocha, Leticia Barboza; Oliveira, Fabiana Freire Mendes deParacoccidioidomycosis (PCM) is one of the most frequent systemic mycoses in Latin America. It affects mainly male rural workers in impoverished regions, and the therapy can last up to two years or use drugs that are very toxic. Given the need for novel safe and effective approaches to treat PCM, we have been developing monoclonal antibodies (mAbs) that could be used not only to block specific fungal targets, b...
A hidden battle in the dirt: Soil amoebae interactions with Paracoccidioides spp
Albuquerque, Patrícia; Nicola, André Moraes; Magnabosco, Diogo Almeida Gomes; da Silveira Derengowski, Lorena; Crisóstomo, Luana SoaresMade available in DSpace on 2020-12-12T01:42:02Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-01-01; Paracoccidioides spp. are thermodimorphic fungi that cause a neglected tropical disease (paracoccidioidomycosis) that is endemic to Latin America. These fungi inhabit the soil, where they live as saprophytes with no need for a mammalian host to complete their life cycle. Despite this, they developed sop...
Pesquisa translacional no Brasil : temas de pesquisa e sua aderência à Agenda d...
Correia, Cinthya Vivianne de Souza Rocha; Rezende, Kellen Santos; Rosa, Suélia de Siqueira Rodrigues Fleury; Barreto, Jorge Otávio MaiaO estudo objetivou prospectar grupos e temas de pesquisa translacional no Brasil, que detenham potencial de transformar pesquisa em soluções para saúde no âmbito nacional, e avaliar se existe convergência com a Agenda de Prioridades de Pesquisa do Ministério da Saúde, a Agenda. Estudo exploratório, descritivo, realizado a partir de busca em bases de dados públicos de acesso livre. Foram localizados 64 programas...
Swine and poultry pathogens: The complete genome sequences of two strains of My...
Vasconcelos, Ana Tereza; Ferreira, Henrique Bunselmeyer; Bizarro, Cristiano Valim; Bonatto, Sandro L.; Carvalho, Marcos O.; Pinto, Paulo MarcosThis work reports the results of analyses of three complete mycoplasma genomes, a pathogenic (7448) and a nonpathogenic (J) strain of the swine pathogen Mycoplasma hyopneumoniae and a strain of the avian pathogen Mycoplasma synoviae; the genome sizes of the three strains were 920,079 bp, 897,405 bp, and 799,476 bp, respectively. These genomes were compared with other sequenced mycoplasma genomes reported in the...
The Genome of Anopheles darlingi, the main neotropical malaria vector
Marinotti, Osvaldo; Cerqueira, Gustavo C.; Almeida, Luiz G.P.; Ferro, Maria Inês Tiraboschi; Loreto, Elgion Lúcio da Silva; Zaha, ArnaldoAnopheles darlingi is the principal neotropical malaria vector, responsible for more than a million cases of malaria per year on the American continent. Anopheles darlingi diverged from the African and Asian malaria vectors ∼100 million years ago (mya) and successfully adapted to the New World environment. Here we present an annotated reference A. darlingi genome, sequenced from a wild population of males and f...
The complete genome sequence of Chromobacterium violaceum reveals remarkable an...
Vasconcelos, Ana Tereza; De-Almeida, Darcy Fontoura; Hungría, Mariangela; Guimarães, Cláudia Teixeira; Antônio, Regina VasconcellosChromobacterium violaceum is one of millions of species of free-living microorganisms that populate the soil and water in the extant areas of tropical biodiversity around the world. Its complete genome sequence reveals (i) extensive alternative pathways for energy generation, (ii) ≈500 ORFs for transport-related proteins, (iii) complex and extensive systems for stress adaptation and motility, and (iv) wide-spre...
Bioinformatics of the Paracoccidioides brasiliensis EST Project
Brígido, Marcelo de Macedo; Walter, Maria Emília Machado Telles; Oliveira, Adilton G.; Inoue, Marcus K.; Anjos, Daniel dos SantosParacoccidioides brasiliensis is the etiological agent of paracoccidioidomycosis, an endemic mycosis of Latin America. This fungus presents a dimorphic character; it grows as a mycelium at room temperature, but it is isolated as yeast from infected individuals. It is believed that the transition from mycelium to yeast is important for the infective process. The Functional and Differential Genome of Paracoccidio...